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1. WO2013053722 - USES OF GROWTH AND DIFFERENTIATION FACTOR 8 (GDF-8)

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Publication Number WO/2013/053722
Publication Date 18.04.2013
International Application No. PCT/EP2012/069986
International Filing Date 10.10.2012
IPC
C12N 5/077 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
CPC
A61K 2035/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
122for inducing tolerance or supression of immune responses
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 38/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
C12N 2501/115
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
115Basic fibroblast growth factor (bFGF, FGF-2)
Applicants
  • BONE THERAPEUTICS S.A. [BE]/[BE]
Inventors
  • ALBARANI, Valentina
  • BASTIANELLI, Enrico
  • BIZIMUNGU, Christelle
  • JOLY, Alice
  • NGUYEN, Xuan Mai
  • TYTGAT, Isabelle
Agents
  • MICHALÍK, Andrej
Priority Data
11184625.911.10.2011EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) USES OF GROWTH AND DIFFERENTIATION FACTOR 8 (GDF-8)
(FR) UTILISATIONS DU FACTEUR DE CROISSANCE ET DE DIFFÉRENCIATION 8 (GDF-8)
Abstract
(EN) The present invention relates to uses of growth and differentiation factor 8 (GDF-8) in vitro or in vivo for reducing the immunogenicity or risk of rejection of cells such as in particular mesenchymal stem cells (MSC), tissues or materials. The present invention further relates to methods for differentiating MSC in vitro or ex vivo into osteoprogemtors or osteoblastic cells or a cell population comprising osteoprogemtors and/or osteoblastic cells using FGF-2 and GDF-8. In addition, the present invention relates to osteoprogemtors or osteoblastic cells or a cell population comprising osteoprogemtors and/or osteoblastic cells obtainable by such methods and to the osteoprogemtors or osteoblastic cells or a cell population comprising osteoprogemtors and/or osteoblastic cells for use in the treatment of musculoskeletal diseases.
(FR) La présente invention concerne des utilisations du facteur de croissance et de différenciation 8 (GDF-8) in vitro ou in vivo afin de réduire l'immunogénicité ou le risque de rejet de cellules, telles que notamment les cellules souches mésenchymateuses (CSM), de tissus ou de substances. La présente invention concerne également des procédés permettant de différencier les CSM in vitro ou ex vivo dans les cellules ostéoprogénitrices ou les cellules ostéoblastiques ou une population de cellules comprenant des cellules ostéoprogénitrices et/ou des cellules ostéoblastiques en utilisant le FGF-2 et le GDF-8. De plus, la présente invention concerne des cellules ostéoprogénitrices ou des cellules ostéoblastiques ou une population de cellules comprenant des cellules ostéoprogénitrices et/ou des cellules ostéoblastiques pouvant être obtenues par de tels procédés et des cellules ostéoprogénitrices ou des cellules ostéoblastiques ou une population de cellules comprenant des cellules ostéoprogénitrices et/ou des cellules ostéoblastiques pour une utilisation dans le traitement de maladies musculo-squelettiques.
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