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1. (WO2013052839) EFFICIENT PROCESSES FOR LARGE SCALE PREPARATION OF PHOSPHAPLATINS ANTITUMOR AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/052839    International Application No.:    PCT/US2012/059016
Publication Date: 11.04.2013 International Filing Date: 05.10.2012
IPC:
A01N 55/02 (2006.01)
Applicants: BOSE, Rathindra, N. [US/US]; (US).
MOGHADDAS, Shadi [US/US]; (US).
DEZVAREH, Homa [US/US]; (US)
Inventors: BOSE, Rathindra, N.; (US).
MOGHADDAS, Shadi; (US).
DEZVAREH, Homa; (US)
Agent: CHEEMA, Sangeeta; Winstead PC P.O. Box 131851 Dallas, TX 75313 (US)
Priority Data:
61/543,540 05.10.2011 US
13/922,917 05.10.2012 US
Title (EN) EFFICIENT PROCESSES FOR LARGE SCALE PREPARATION OF PHOSPHAPLATINS ANTITUMOR AGENTS
(FR) PROCÉDÉS EFFICACES POUR LA PRÉPARATION À GRANDE ÉCHELLE D'AGENTS ANTI-TUMORAUX PHOSPHAPLATINES
Abstract: front page image
(EN)An efficient process for synthesizing phosphaplatins in large quantities is disclosed by adding platinum complex to a concentrated pyrophosphate solution at pH from between about 6.0 to 8.5. After stirring, the temperature and pH are lowered to precipitate out desired phosphaplatins. Particularly, the disclosed processes reduce the need to use large volumes of starting materials, and shorten the reaction time. In addition, disclosed is a process for recycling un-reacted materials from a first phosphaplatins synthesis.
(FR)L'invention concerne un procédé efficace de synthèse de phosphaplatines en grandes quantités par l'addition d'un complexe du platine à une solution de pyrophosphate concentrée à un pH entre environ 6,0 et 8,5. Après l'agitation, la température et le pH sont abaissés pour précipiter les phosphaplatines souhaitées. En particulier, les procédés de l'invention réduisent le besoin d'utiliser de grands volumes de matières premières, et diminuent la durée de réaction. De plus, l'invention concerne un procédé de recyclage de matières n'ayant pas réagi à partir d'une première synthèse de phosphaplatines.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)