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1. (WO2013052787) MEMBRANE ACTIVATED CHELATORS AND USE IN THE PREVENTION AND TREATMENT OF PARASITIC INFECTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/052787    International Application No.:    PCT/US2012/058932
Publication Date: 11.04.2013 International Filing Date: 05.10.2012
IPC:
A61K 31/138 (2006.01), A61K 31/137 (2006.01), A61K 31/133 (2006.01), A61P 25/00 (2006.01), A61P 9/00 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 North Charles Street Baltimore, Maryland 21218 (US) (For All Designated States Except US).
GRAB, Dennis John [US/US]; (US) (US only)
Inventors: GRAB, Dennis John; (US)
Agent: CONTRERA, Joseph; 100 N. Charles Street 5th Floor Baltimore, Maryland 21201 (US)
Priority Data:
61/543,564 05.10.2011 US
61/543,575 05.10.2011 US
Title (EN) MEMBRANE ACTIVATED CHELATORS AND USE IN THE PREVENTION AND TREATMENT OF PARASITIC INFECTION
(FR) CHÉLATEURS ACTIVÉS AU NIVEAU DE LA MEMBRANE ET LEUR UTILISATION DANS LA PRÉVENTION ET LE TRAITEMENT D'INFECTIONS PARASITAIRES
Abstract: front page image
(EN)Provided herein are pharmaceutical compositions useful in the prevention and treatment of protozoan infections in mammals comprising administering to the subject a pharmaceutical composition comprising at least one membrane activated chelator compound which is a lipophilic diester derivative of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, or a salt, solvate, stereoisomer, or prodrug thereof, as well as compositions which include at least one or more other anti-parasitic compound, and a pharmaceutically acceptable carrier, in an effective amount. Methods for prevention, treatment, and combination therapies are also provided.
(FR)La présente invention porte sur des compositions pharmaceutiques utiles dans la prévention et le traitement d'infections à protozoaires chez des mammifères, comprenant l'administration au sujet d'une composition pharmaceutique comprenant au moins un chélateur activé au niveau de la membrane, qui est un dérivé de diester lipophile de l'agent chélateur acide 1,2-bis(2-aminophénoxy)éthane-N,N,N',N'-tétraacétique, ou un sel, solvate, stéréoisomère ou promédicament de celui-ci, ainsi que sur des compositions qui comprennent au moins un ou plusieurs autres composés antiparasitaires et un véhicule pharmaceutiquement acceptable, en une quantité efficace. L'invention porte également sur des procédés pour la prévention, le traitement et des polythérapies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)