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1. (WO2013052745) PREDICTING TUMOR RESPONSE TO ANTI-ERBB3 ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/052745    International Application No.:    PCT/US2012/058871
Publication Date: 11.04.2013 International Filing Date: 05.10.2012
IPC:
G01N 33/574 (2006.01)
Applicants: AVEO PHARMACEUTICALS, INC. [US/US]; 650 E. Kendall Street Cambridge, MA 02142 (US)
Inventors: VINCENT, Sylvie; (US).
MEETZE, Kristan; (US).
FENG, Bin; (US).
TYLER, Steven; (US).
BOTTEGA, Steve; (US).
NICOLETTI, Richard; (US).
MCINTOSH, Donna; (US).
GYURIS, Jeno; (US)
Agent: GUSTAFSON, Megan, A.; Goodwin Procter LLP Exchange Place Boston, MA 02109 (US)
Priority Data:
61/636,183 20.04.2012 US
61/544,206 06.10.2011 US
Title (EN) PREDICTING TUMOR RESPONSE TO ANTI-ERBB3 ANTIBODIES
(FR) PRÉDICTION DE RÉACTION DE TUMEUR À DES ANTICORPS ANTI-ERBB3
Abstract: front page image
(EN)A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.
(FR)L'invention concerne une méthode de diagnostic qui permet de prédire quantitativement si une tumeur humaine sera sensible ou résistante à un traitement par un inhibiteur d'ERBB3, par exemple un anticorps anti-ERBB3. La méthode repose sur la mesure de l'expression de NRG1 au niveau de l'ARN ou au niveau de la protéine, dans un prélèvement de tissu de la tumeur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)