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Machine translation
1. (WO2013052727) METHODS OF TREATMENT USING MODULATORS OF SIRT2
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/052727    International Application No.:    PCT/US2012/058846
Publication Date: 11.04.2013 International Filing Date: 05.10.2012
IPC:
C07C 327/42 (2006.01), A61K 31/16 (2006.01), A61P 25/28 (2006.01), A61P 35/00 (2006.01)
Applicants: CORNELL UNIVERSITY [US/US]; Cornell Center for Technology, Enterprise & Commercialization 395 Pine Tree Road Suite 310 Ithaca, New York 14850 (US) (For All Designated States Except US).
LIN, Hening [CN/US]; (US) (US only).
HE, Bin [CN/US]; (US) (US only)
Inventors: LIN, Hening; (US).
HE, Bin; (US)
Agent: GROLZ, Edward W.; Scully, Scott, Murphy & Presser 400 Garden City Plaza Suite 300 Garden City, New York 11530 (US)
Priority Data:
61/544,452 07.10.2011 US
Title (EN) METHODS OF TREATMENT USING MODULATORS OF SIRT2
(FR) MÉTHODES DE TRAITEMENT UTILISANT DES MODULATEURS DE LA SIRT2
Abstract: front page image
(EN)The instant application describes novel compounds that modulate (in particular, inhibit) Sirt2, with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof, methods of treatment (i.e., cancer and neurodegenerative disease) by administration of the modulating compounds, assay methods for finding modulators of Sirt2, and kits for practicing the assay method.
(FR)La présente invention concerne de nouveaux composés qui modulent (et en particulier inhibent) la sirt2, et qui possèdent des structures conformes aux formules (1) et (2). L'invention porte en outre sur des compositions pharmaceutiques afférentes, et sur des méthodes de traitement (du cancer et de maladies neuro-dégénératives) par l'administration desdits composés de modulation. L'invention a également trait à des procédés de criblage permettant de découvrir des modulateurs de la sirt2, et à des kits permettant de mettre en œuvre lesdits procédés de criblage.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)