WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2013052677) COMPOSITIONS AND METHODS FOR SILENCING ALDEHYDE DEHYDROGENASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/052677    International Application No.:    PCT/US2012/058770
Publication Date: 11.04.2013 International Filing Date: 04.10.2012
IPC:
C07H 21/02 (2006.01), C12N 15/11 (2006.01)
Applicants: PROTIVA BIOTHERAPEUTICS INC. [CA/CA]; 100 - 8900 Glenlyon Parkway Burnaby, British Columbia V5J 5J8 (CA)
Inventors: MACLACHLAN, Ian; (CA).
LEE, Amy C.H.; (CA)
Agent: LAHERTY, Carol D.; Cooley LLP 777 - 6th Street, NW Suite 1100 Washington, District of Columbia 20001 (US)
Priority Data:
61/543,700 05.10.2011 US
61/599,238 15.02.2012 US
Title (EN) COMPOSITIONS AND METHODS FOR SILENCING ALDEHYDE DEHYDROGENASE
(FR) COMPOSITIONS ET PROCÉDÉS PERMETTANT DE RÉPRIMER L'EXPRESSION DE L'ALDÉHYDE DÉSHYDROGÉNASE
Abstract: front page image
(EN)The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target aldehyde dehydrogenase (ALDH) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating alcoholism in humans).
(FR)L'invention se rapporte à des compositions qui renferment des acides nucléiques thérapeutiques, tels qu'un ARN d'interférence (p.ex. un ARNds comme l'ARNsi), qui ciblent l'expression du gène de l'aldéhyde déshydrogénase. L'invention concerne aussi des particules lipidiques renfermant un ou plusieurs acides nucléiques thérapeutiques (p.ex. un cocktail), des procédés de fabrication desdites particules lipidiques et des procédés de distribution et/ou d'administration des particules lipidiques (p.ex. pour traiter l'alcoolisme chez des humains).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)