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1. WO2013052180 - METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION

Publication Number WO/2013/052180
Publication Date 11.04.2013
International Application No. PCT/US2012/042381
International Filing Date 14.06.2012
IPC
A61N 1/36 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation, e.g. heart pace-makers
CPC
A61B 5/04001
A61B 5/6868
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
6846specially adapted to be brought in contact with an internal body part, i.e. invasive
6867specially adapted to be attached or implanted in a specific body part
6868Brain
A61N 1/0529
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
02Details
04Electrodes
05for implantation or insertion into the body, e.g. heart electrode
0526Head electrodes
0529Electrodes for brain stimulation
A61N 1/0531
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
02Details
04Electrodes
05for implantation or insertion into the body, e.g. heart electrode
0526Head electrodes
0529Electrodes for brain stimulation
0531Brain cortex electrodes
A61N 1/0536
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
02Details
04Electrodes
05for implantation or insertion into the body, e.g. heart electrode
0526Head electrodes
0529Electrodes for brain stimulation
0536Preventing neurodegenerative response or inflammatory reaction
A61N 1/36103
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation
3605Implantable neurostimulators for stimulating central or peripheral nerve system
3606adapted for a particular treatment
36103Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
Applicants
  • UNIVERSITY OF KANSAS [US]/[US] (AllExceptUS)
  • CASE WESTERN RESERVE UNIVERSITY [US]/[US] (AllExceptUS)
  • NUDO, Randolph, J. [US]/[US] (UsOnly)
  • AZIN, Meysam [IR]/[US] (UsOnly)
  • MOHSENI, Pedram [IR]/[US] (UsOnly)
  • GUGGENMOS, David [US]/[US] (UsOnly)
Inventors
  • NUDO, Randolph, J.
  • AZIN, Meysam
  • MOHSENI, Pedram
  • GUGGENMOS, David
Agents
  • RIDDLE, Robert
Priority Data
61/543,59305.10.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION
(FR) PROCÉDÉS ET DISPOSITIFS PROSTHÉTIQUES NEURAUX ASSOCIÉS PERMETTANT DE PONTER DES ZONES DU CERVEAU AFIN D'AMÉLIORER LES FONCTIONS VITALES
Abstract
(EN) Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided herein. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. Although any neural prosthetic device capable of detecting a spike in a first site and delivering a stimulus in a second site may be used, the present disclosure further provides a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.
(FR) La présente invention se rapporte à des procédés de pontage de sites cérébraux entre lesquels il n'y a sensiblement pas de communication effective, et à des dispositifs prosthétiques neuronaux associés. Une impulsion neurale dans un premier site neural chez un sujet est détectée et un stimulus à un second site neural chez le sujet est délivré pendant une période de temps définie après la détection de l'impulsion neurale, il n'y a sensiblement aucune communication effective entre les premier et second sites neuraux. Le procédé forme un pont artificiel entre les deux sites neuraux et établit une communication durable entre les deux sites. Bien qu'un dispositif prosthétique neural qui peut détecter une impulsion dans le premier site et délivrer un stimulus dans un second site, puisse être utilisé, la présente invention porte en outre sur un dispositif prosthétique neuraux qui comprend un circuit intégré qui comprend un module frontal d'enregistrement qui comprend une pluralité de canaux d'enregistrement ; une unité à processeur ; et un module arrière délivrant des stimuli qui comprend une pluralité de canaux de stimulation.
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