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1. (WO2013052157) CRYSTALLINE FORMS OF AFATINIB DI-MALEATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/052157    International Application No.:    PCT/US2012/034903
Publication Date: 11.04.2013 International Filing Date: 25.04.2012
IPC:
C07D 407/12 (2006.01), A61K 31/517 (2006.01), A61P 35/00 (2006.01)
Applicants: RATIOPHARM GMBH [DE/DE]; Graf-Arco-Strasse 3 89079 Ulm (DE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road P.O. Box 1090 North Wales, PA 19454-1090 (US) (BB only).
BRUNS, Anja [DE/DE]; (DE) (For US Only).
EICHNER, Simone [DE/DE]; (DE) (For US Only).
LEHMANN, Frank [DE/DE]; (DE) (For US Only).
ALBRECHT, Wolfgang [DE/DE]; (DE) (For US Only).
MAIER, Annemarie [DE/DE]; (DE) (For US Only)
Inventors: BRUNS, Anja; (DE).
EICHNER, Simone; (DE).
LEHMANN, Frank; (DE).
ALBRECHT, Wolfgang; (DE).
MAIER, Annemarie; (DE)
Agent: VALLA, S. Maurice; Baker & Hostetler LLP Cira Centre, 12th Floor 2929 Arch Street Philadelphia, PA 19104-2891 (US)
Priority Data:
61/544,108 06.10.2011 US
61/590,431 25.01.2012 US
Title (EN) CRYSTALLINE FORMS OF AFATINIB DI-MALEATE
(FR) FORMES CRISTALLINES DE DI-MALÉATE D'AFATINIB
Abstract: front page image
(EN)Crystalline forms of Afatinib di-maleate are described in the present application and processes for their preparation. The present invention also includes pharmaceutical compositions of such crystalline forms of Afatinib di-maleate, methods of their preparation and the use thereof hi the treatment of a patient in need thereof. The present invention also describes preparing Afatinib free base and salts of Afatinib, other than Afatibin di-maleate, and solid forms thereof.
(FR)L'invention concerne des formes cristallines de di-maléate d'Afatinib et des procédés pour leur préparation. La présente invention concerne également des compositions pharmaceutiques de telles formes cristallines de di-maléate d'Afatinib, des procédés pour leur préparation et leur utilisation dans le traitement d'un patient en ayant besoin. La présente invention concerne également la préparation de base libre d'Afatinib et de sels d'Afatinib, autres que le di-maléate d'Afatinib, et leurs formes solides.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)