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1. (WO2013052155) METHODS OF TREATING LIVER CONDITIONS USING NOTCH2 ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2013/052155 International Application No.: PCT/US2012/032621
Publication Date: 11.04.2013 International Filing Date: 06.04.2012
IPC:
C07K 16/28 (2006.01) ,A61P 1/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants:
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (AE, AG, AM, AO, AU, AZ, BA, BB, BF, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PE, PG, PH, QA, RU, RW, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
FRENCH, Dorothy [US/US]; US (UsOnly)
SIEBEL, Christian W. [US/US]; US (UsOnly)
HUNTZICKER, Erik [US/US]; US (UsOnly)
Inventors:
FRENCH, Dorothy; US
SIEBEL, Christian W.; US
HUNTZICKER, Erik; US
Agent:
VOM WEGE, Julia; c/o Genentech, Inc. 1 DNA Way, MS49 South San Francisco, California 94080, US
Priority Data:
61/543,48305.10.2011US
Title (EN) METHODS OF TREATING LIVER CONDITIONS USING NOTCH2 ANTAGONISTS
(FR) MÉTHODES DE TRAITEMENT DE TROUBLES HÉPATIQUES METTANT EN ŒUVRE DES ANTAGONISTES DE NOTCH2
Abstract:
(EN) Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include, but are not limited to, chronic liver disease.
(FR) La présente invention concerne des méthodes et des compositions pour le traitement de troubles hépatiques, lesdites méthodes et compositions comportant des antagonistes de Notch2, par exemple, des anticorps anti-Notch2. Les troubles hépatiques comprennent, entre autres, la maladie du foie chronique.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
TR2014/03898CA2849011MX2014004074US20150064186SG11201401287SAU2012319150
BR112014008212AU2017208253MYPI 2014001007