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Machine translation
1. (WO2013052110) NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/052110    International Application No.:    PCT/US2012/000459
Publication Date: 11.04.2013 International Filing Date: 03.10.2012
IPC:
A01N 37/18 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; West 116th Street And Broadway New York, NY 10027 (US) (For All Designated States Except US).
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH [US/US]; 1275 York Avenue New York, NY 10065 (US) (For All Designated States Except US).
BRESLOW, Ronald [US/US]; (US) (US only).
MARKS, Paul, A. [US/US]; (US) (US only)
Inventors: BRESLOW, Ronald; (US).
MARKS, Paul, A.; (US)
Agent: WHITE, John, P.; Cooper & Dunham LLP 30 Rockefeller Plaza New York, NY 10112 (US)
Priority Data:
61/620,783 05.04.2012 US
61/542,598 03.10.2011 US
Title (EN) NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1
(FR) NOUVELLES MOLÉCULES QUI INHIBENT SÉLECTIVEMENT L'HISTONE-DÉACÉTYLASE 6 PAR RAPPORT À L'HISTONE-DÉACÉTYLASE 1
Abstract: front page image
(EN)The compounds of the present invention are HDAC6 selective inhibitors which are identified on the basis of accumulation of acetylated tubulin without accumulation of acetylated histones. Histone deacetylase or "HDAC" refers to enzymes capable of cleaving an acetyl group (-C(=0)CH3) from proteins, including histone and microtubulins. Compositions comprising the molecules and methods for their use to inhibit the activity of histone deacetylase, including for treatment, are also disclosed.
(FR)Les composés de la présente invention sont des inhibiteurs sélectifs de HDAC6 qui sont identifiés sur la base de l'accumulation de tubuline acétylée sans accumulation d'histones acétylées. L'histone-déacétylase ou « HDAC » fait référence à des enzymes aptes à cliver un groupe acétyle (‑C(=0)CH3) à partir de protéines, comprenant une histone et des microtubulines. L'invention concerne également des compositions comportant les molécules et des procédés pour leur utilisation pour inhiber l'activité de l'histone-déacétylase, y compris pour le traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)