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1. (WO2013051938) CYCLIC ANALOGS OF GLP-1 AND GLP-1 RELATED PEPTIDES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/051938    International Application No.:    PCT/NL2012/050699
Publication Date: 11.04.2013 International Filing Date: 08.10.2012
IPC:
C07K 14/605 (2006.01)
Applicants: LANTHIOPEP B.V. [NL/NL]; Nijenborgh 4 NL-9747 AG Groningen (NL)
Inventors: KUIPERS, Anneke; (NL).
DE VRIES, Louwe; (NL).
BOSMA, Tjibbe; (NL).
RINK, Rick; (NL).
MOLL, Gert Nikolaas; (NL)
Agent: JANSEN, C.M.; V.O. Johan de Wittlaan 7 NL-2517 JR Den Haag (NL)
Priority Data:
11184392.6 07.10.2011 EP
Title (EN) CYCLIC ANALOGS OF GLP-1 AND GLP-1 RELATED PEPTIDES AND USES THEREOF
(FR) ANALOGUES PEPTIDIQUES CYCLIQUES DE GLP-1 OU DE PEPTIDES APPARENTÉS À GLP-1 ET LEURS UTILISATIONS
Abstract: front page image
(EN)The invention relates to cyclic peptide analogs of GLP-1 or of a GLP- -related peptide, comprising at least one enzymatically formed intramolecular lysinoalanine linkage between the side chains of two amino acids. The invention also relates to methods for the preparation of such cyclic peptide analogs and to the use thereof in therapy, for example metabolic diseases, neurological or neurodegenerative diseases and cardiovascular diseases.
(FR)L'invention concerne des analogues peptidiques cycliques de GLP-1 ou d'un peptide apparenté à GLP-1, qui comprend au moins une liaison lysino-alanine intramoléculaire formée par voie enzymatique entre les chaînes latérales de deux acides aminés. L'invention concerne également des procédés de préparation desdits analogues peptidiques cycliques et leur utilisation à des fins thérapeutique, notamment contre les maladies métaboliques, les maladies neurologiques ou neurodégénératives et les maladies cardiovasculaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)