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1. (WO2013051883) METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)-PROP-2-EN-1-ONE HYDROCHLORIDE AND INTERMEDIATES USED THEREIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/051883    International Application No.:    PCT/KR2012/008077
Publication Date: 11.04.2013 International Filing Date: 05.10.2012
IPC:
C07D 401/12 (2006.01), A61K 31/517 (2006.01)
Applicants: HANMI SCIENCE CO., LTD. [KR/KR]; 550, Dongtangiheung-ro, Dongtan-myeon, Hwaseong-si, Gyeonggi-do 445-813 (KR)
Inventors: BANG, Keuk Chan; (KR).
MOON, Young Ho; (KR).
CHANG, Young Kil; (KR)
Agent: FIRSTLAW P.C.; Trust Tower, 275-7 Yangjae-Dong, Seocho-Ku, Seoul 137-739 (KR)
Priority Data:
10-2011-0101422 05.10.2011 KR
Title (EN) METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)-PROP-2-EN-1-ONE HYDROCHLORIDE AND INTERMEDIATES USED THEREIN
(FR) PROCÉDÉ DE PRÉPARATION DU CHLORHYDRATE DE 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHÉNYLAMINO)-7-MÉTHOXYQUINAZOLIN-6-YLOXY)PIPÉRIDIN-1-YL)-PROP-2-ÈN-1-ONE ET INTERMÉDIAIRES UTILISÉS AU COURS DUDIT PROCÉDÉ DE PRÉPARATION
Abstract: front page image
(EN)The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase, and intermediates used therein.
(FR)La présente invention concerne un procédé amélioré de préparation du chlorhydrate de 1-(4-(4-(3,4-dichloro-2-fluorophénylamino)-7-méthoxyquinazolin-6-yloxy)pipéridin-1-yl)-prop-2-èn-1-one, qui inhibe sélectivement et efficacement la croissance de cellules cancéreuses induite par la surexpression d'un récepteur du facteur de croissance épidermique (EGFR) et prévient le développement d'une résistance aux médicaments due à une mutation d'une tyrosine kinase. L'invention concerne également les intermédiaires utilisés au cours dudit procédé de préparation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)