WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2013051625) METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/051625    International Application No.:    PCT/JP2012/075705
Publication Date: 11.04.2013 International Filing Date: 03.10.2012
IPC:
C12N 5/0789 (2010.01), A61K 35/14 (2006.01), A61P 7/04 (2006.01), C12N 5/0735 (2010.01), C12N 5/078 (2010.01), C12N 5/10 (2006.01), C07D 333/38 (2006.01)
Applicants: NISSAN CHEMICAL INDUSTRIES, LTD. [JP/JP]; 7-1, Kanda-Nishiki-cho 3-chome, Chiyoda-ku, Tokyo 1010054 (JP).
THE UNIVERSITY OF TOKYO [JP/JP]; (JP)
Inventors: NISHINO, Taito; (JP).
NAKAMURA, Takanori; (JP).
IWAMOTO, Shunsuke; (JP).
ETO, Koji; (JP).
NAKAUCHI, Hiromitsu; (JP).
TSUJI, Kayoko; (JP)
Agent: SENMYO, Kenji; 4th Floor, SIA Kanda Square, 17, Kanda-konyacho, Chiyoda-ku, Tokyo 1010035 (JP)
Priority Data:
2011-219545 03.10.2011 JP
Title (EN) METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
(FR) PROCÉDÉ DE PRODUCTION DE MÉGACARYOCYTES ET/OU DE PLAQUETTES À PARTIR DE CELLULES SOUCHES PLURIPOTENTES
(JA) 多能性幹細胞からの巨核球及び/又は血小板の製造方法
Abstract: front page image
(EN)Provided is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells, the inducing agent being useful in treating diseases involving thrombopenia. A method for producing megakaryocytes and/or platelets, the method comprising: separating hematopoietic progenitor cells and cells that form a septum of a net-like structure produced by pluripotent stem cells, in the presence of a compound represented by formula (I) (R1-R7, W, X, Y, Z, Ar1, and n in the formula are defined in the specification), a tautomer of the compound, a prodrug, a pharmaceutically acceptable salt of these, or a solvate of these compounds; culturing the resulting hematopoietic progenitor cells in vitro; and differentiating the same into megakaryocytes and/or platelets.
(FR)Cette invention concerne un agent inducteur de mégacaryocytes et/ou de plaquettes à partir de cellules souches pluripotentes, ledit agent inducteur étant utile pour traiter les maladies impliquant la thrombopénie ; et un procédé de production de mégacaryocytes et/ou de plaquettes, ledit procédé comprenant : la séparation des cellules progénitrices hématopoïétiques et des cellules qui forment une cloison constituée d'une structure de type filet produite par les cellules souches pluripotentes, en présence d'un composé représenté par la formule (I) (R1-R7, W, X, Y, Z, Ar1, et n dans la formule sont définis dans la description), d'un tautomère dudit composé, d'un promédicament, d'un sel pharmaceutiquement acceptable de ceux-ci, ou un solvate de ces composés ; la culture des cellules progénitrices hématopoïétiques obtenues in vitro ; et leur différenciation en mégacaryocytes et/ou plaquettes.
(JA) 血小板減少を伴う疾患に対する治療に有用である、多能性幹細胞からの巨核球及び/又は血小板の誘導剤を提供する。 下記式(I)(式中のR~R、W、X、Y、Z、Ar及びnは、明細書中において定義される。)で表される化合物、該化合物の互変異性体、プロドラッグ、それらの医薬的に許容され得る塩又はそれら化合物の溶媒和物の存在下、多能性幹細胞が産生するネット様構造物の隔壁を形成する細胞と造血前駆細胞を分離し、得られた造血前駆細胞を生体外で培養して巨核球及び/又は血小板に分化させる、巨核球及び/又は血小板の製造方法。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)