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1. (WO2013050567) PHOSPHOSPECIFIC ANTIBODIES RECOGNISING TAU
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/050567    International Application No.:    PCT/EP2012/069783
Publication Date: 11.04.2013 International Filing Date: 05.10.2012
IPC:
C07K 16/18 (2006.01), G01N 33/68 (2006.01), A61K 39/00 (2006.01)
Applicants: AC IMMUNE S.A. [CH/CH]; PSE-Building B- EPFL CH-1015 Lausanne (CH) (For All Designated States Except US).
KATHOLIEKE UNIVERSITEIT LEUVEN [BE/BE]; KU Leuven Research & Development Waaistraat 6 - box 5105 B-3000 Leuven (BE) (For All Designated States Except US).
PFEIFER, Andrea [DE/CH]; (CH) (US only).
MUHS, Andreas [DE/CH]; (CH) (US only).
PIHLGREN, Maria [SE/CH]; (CH) (US only).
ADOLFSSON, Oskar [IS/CH]; (CH) (US only).
VAN LEUVEN, Fred [BE/BE]; (BE) (US only)
Inventors: PFEIFER, Andrea; (CH).
MUHS, Andreas; (CH).
PIHLGREN, Maria; (CH).
ADOLFSSON, Oskar; (CH).
VAN LEUVEN, Fred; (BE)
Agent: JONES DAY; Prinzregentenstr. 11 80538 Munich (DE)
Priority Data:
PCT/EP2011/067604 07.10.2011 EP
12163319.2 05.04.2012 EP
Title (EN) PHOSPHOSPECIFIC ANTIBODIES RECOGNISING TAU
(FR) ANTICORPS PHOSPHOSPÉCIFIQUES RECONNAISSANT TAU
Abstract: front page image
(EN)The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles, in particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
(FR)La présente invention concerne des procédés et des compositions pour le traitement et le diagnostic dans le cadre du traitement de maladies et de troubles qui sont causés par ou associés avec les enchevêtrements neurofibrillaires. L'invention concerne notamment des anticorps qui reconnaissent et se lient spécifiquement avec des conformères de la protéine tau pathologiques phosphorylés, et des procédés et des compositions utilisant lesdits anticorps pour le traitement et le diagnostic dans le cadre du traitement de tauopathies, y compris la maladie d'Alzheimer (AD).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)