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1. WO2013050554 - CARBOHYDRATE FUNCTIONALISED SURFACES

Publication Number WO/2013/050554
Publication Date 11.04.2013
International Application No. PCT/EP2012/069762
International Filing Date 05.10.2012
IPC
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
A61L 27/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
CPC
A61L 27/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
28Materials for coating prostheses
34Macromolecular materials
A61L 29/085
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
29Materials for catheters, ; medical tubing, cannulae, or endoscopes; or for coating catheters
08Materials for coatings
085Macromolecular materials
A61L 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
08Materials for coatings
10Macromolecular materials
C07H 15/203
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
G01N 33/54353
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54353with ligand attached to the carrier via a chemical coupling agent
Applicants
  • THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN [IE]/[IE]
Inventors
  • SCANLAN, Eoin M.
  • COLAVITA, Paula E.
  • MURPHY, Deirdre
  • BOURKE, Jean
Agents
  • MUNROE, Mary Jacqueline
Priority Data
11184038.505.10.2011EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CARBOHYDRATE FUNCTIONALISED SURFACES
(FR) SURFACES FONCTIONNALISÉES PAR HYDRATES DE CARBONE
Abstract
(EN) Carbohydrates are biomolecules that are involved in a range of biological processes and play key roles in, for instance, host immune response and cellular adhesion. Accordingly, functionalisation of medical devices such as stents, valves, catheters, prostheses and other devices for in vivoimplantation with carbohydrates is an area in which considerable interest is developing. Disclosed herein are surfaces having carbohydrates immobilised thereon. The carbohydrate has a linker moiety covalently bound thereto and the linker moiety has a carbon atom that forms a covalent bond with an atom on the target surface. The carbon based bond is a strong, non-hydrolysable covalent bond. Diazonium salts are utilised to produce the functionalised surfaces and they are particularly advantageous as they result in non-toxic readily escapable by-products
(FR) Les hydrates de carbone sont des biomolécules impliquées dans toute une plage de processus biologiques dans lesquelles elles jouent un rôle clé, comme la réponse immune de l'hôte et l'adhésion cellulaire. Ainsi, la fonctionnalisation de dispositifs médicaux comme les stents, les valves, les cathéters, les prothèses et autres dispositifs pour implantation in vivo à l'aide d'hydrates de carbone est un domaine pour lequel un intérêt considérable se développe. L'invention concerne des surfaces sur lesquelles sont immobilisés des hydrates de carbone. L'hydrate de carbone comprend une fraction de liaison liée de manière covalente à celui-ci, et la fraction de liaison comprend un atome de carbone qui forme une liaison covalente avec un atome sur la surface cible. La liaison à base de carbone est une liaison covalente forte et non hydrolysable. Des sels de diazonium sont utilisés pour produire les surfaces fonctionnalisées et sont particulièrement avantageux du fait qu'ils permettent d'obtenir des produits dérivés non toxiques et qui disparaissent facilement.
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