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1. (WO2013050446) SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASES INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/050446    International Application No.:    PCT/EP2012/069586
Publication Date: 11.04.2013 International Filing Date: 04.10.2012
IPC:
C07D 487/04 (2006.01), A61K 31/4985 (2006.01), A61P 35/00 (2006.01)
Applicants: NERVIANO MEDICAL SCIENCES S.R.L. [IT/IT]; PO Box 11 Viale Pasteur, 10 I-20014 Nerviano (MI) (IT)
Inventors: CASUSCELLI, Francesco; (IT).
CASALE, Elena; (IT).
MONTEMARTINI, Marisa; (IT).
PIUTTI, Claudia; (IT)
Priority Data:
11184337.1 07.10.2011 EP
Title (EN) SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASES INHIBITORS
(FR) DÉRIVÉS 3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE SUBSTITUÉS EN TANT QU'INHIBITEURS DE KINASES
Abstract: front page image
(EN)The present invention relates to substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
(FR)La présente invention concerne des dérivés 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one substitués qui modulent l'activité de protéine kinases et sont par conséquent utiles dans le traitement de maladies provoquées par une activité protéine kinase dérégulée. La présente invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques comprenant ces composés et des méthodes de traitement de maladies à l'aide de tels composés ou des compositions pharmaceutiques les contenant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)