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1. (WO2013049727) IDENTIFICATION OF ANTIGEN-SPECIFIC ADAPTIVE IMMUNE RESPONSES USING ARM-PCR AND HIGH-THROUGHPUT SEQUENCING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/049727    International Application No.:    PCT/US2012/058128
Publication Date: 04.04.2013 International Filing Date: 28.09.2012
IPC:
C12P 21/08 (2006.01), C07K 14/00 (2006.01), G06F 19/16 (2011.01)
Applicants: CB BIOTECHNOLOGIES, INC. [US/US]; 7712 Donegal Drive Huntsville, Alabama 35802 (US).
HAN, Jian [US/US]; (US).
BYRNE-STEELE, Miranda [US/US]; (US) (US only)
Inventors: HAN, Jian; (US).
BYRNE-STEELE, Miranda; (US)
Agent: RUSSELL, Donna; 1492 Anthony Way Mount Juliet, Tennessee 37122 (US)
Priority Data:
61/540,454 28.09.2011 US
Title (EN) IDENTIFICATION OF ANTIGEN-SPECIFIC ADAPTIVE IMMUNE RESPONSES USING ARM-PCR AND HIGH-THROUGHPUT SEQUENCING
(FR) IDENTIFICATION DE RÉPONSES IMMUNITAIRES ADAPTATIVES SPÉCIFIQUES À UN ANTIGÈNE UTILISANT L'ARM-PCR ET LE SÉQUENÇAGE À RENDEMENT ÉLEVÉ
Abstract: front page image
(EN)Disclosed is a method for correlating at least one amino acid sequence from an antibody isolated from human or animal blood with at least one DNA sequence corresponding to the antibody in the immunorepertoire of the human or animal. The method also provides a means for pairing heavy and light chains to produce synthesized monoclonal antibodies.
(FR)La présente invention concerne un procédé pour corréler au moins une séquence d'acides aminés d'un anticorps isolé à partir de sang humain ou animal avec au moins une séquence d'ADN correspondant à l'anticorps dans le répertoire immunologique de l'humain ou animal. Le procédé constitue en outre un moyen pour apparier des chaînes lourdes et légères pour produire des anticorps monoclonaux synthétiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)