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Machine translation
1. (WO2013049722) COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/049722    International Application No.:    PCT/US2012/058121
Publication Date: 04.04.2013 International Filing Date: 28.09.2012
IPC:
C07D 413/14 (2006.01), A61K 31/497 (2006.01), A61P 35/00 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street Cambridge, MA 02139 (US) (For All Designated States Except US).
CHARRIER, Jean-Damien [FR/GB]; (GB) (US only).
STORCK, Pierre-Henri [FR/GB]; (GB) (US only).
STUDLEY, John [GB/GB]; (GB) (US only).
PIERARD, Francoise Yvonne, Theodora Marie [BE/GB]; (GB) (US only).
DURRANT, Steven, John [GB/GB]; (GB) (US only).
LITTLER, Benjamin, Joseph [GB/US]; (US) (US only).
ANGELL, Paul; (US only).
HUGHES, Robert, Michael [GB/US]; (US) (US only).
SIESEL, David, Andrew [US/US]; (US) (US only).
URBINA, Armando [US/US]; (US) (US only).
ZWICKER, Carl [US/US]; (US) (US only).
LOCONTE, Nicholas; (US only).
BARDER, Timothy; (US only)
Inventors: CHARRIER, Jean-Damien; (GB).
STORCK, Pierre-Henri; (GB).
STUDLEY, John; (GB).
PIERARD, Francoise Yvonne, Theodora Marie; (GB).
DURRANT, Steven, John; (GB).
LITTLER, Benjamin, Joseph; (US).
ANGELL, Paul; .
HUGHES, Robert, Michael; (US).
SIESEL, David, Andrew; (US).
URBINA, Armando; (US).
ZWICKER, Carl; (US).
LOCONTE, Nicholas; .
BARDER, Timothy;
Agent: CHE, Jennifer, G.; Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge, Massachusetts 02139 (US)
Priority Data:
61/554,174 01.11.2011 US
61/541,861 30.09.2011 US
61/620,698 05.04.2012 US
Title (EN) COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
(FR) COMPOSÉS UTILES COMME INHIBITEURS DE KINASE ATR
Abstract: front page image
(EN)The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I-l : wherein the variables are as defined herein. Additionally, the compounds of this invention have formula II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.
(FR)La présente invention concerne des composés utiles comme inhibiteurs de protéine kinase ATR. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant les composés de cette invention, des procédés de traitement de divers maladies, troubles et affections au moyen des composés de cette invention, des procédés de préparation des composés de cette invention, des intermédiaires pour la préparation des composés de cette invention, des formes solides des composés de cette invention, et des procédés d'utilisation des composés dans des applications in vitro, comme l'étude des kinases dans des phénomènes biologiques et pathologiques, l'étude des voies de transduction de signaux intracellulaires médiées par ces kinases, et l'évaluation comparative de nouveaux inhibiteurs de kinase. Les composés de cette invention ont la formule I-1, dans laquelle les variables sont définies ici. En outre, les composés de cette invention ont la formule II, ou un sel pharmaceutiquement acceptable de celle-ci, dans laquelle les variables sont définies ici.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)