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Machine translation
1. (WO2013049720) COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/049720    International Application No.:    PCT/US2012/058119
Publication Date: 04.04.2013 International Filing Date: 28.09.2012
IPC:
C07D 413/14 (2006.01), A61P 35/00 (2006.01), A61K 31/501 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street Cambridge, MA 02139 (US) (For All Designated States Except US).
CHARRIER, Jean-Damien [FR/GB]; (GB) (US only).
STORCK, Pierre-Henri [FR/GB]; (GB) (US only).
STUDLEY, John [GB/GB]; (GB) (US only).
PIERARD, Francoise, Yvonne Theodora Marie [BE/GB]; (GB) (US only)
Inventors: CHARRIER, Jean-Damien; (GB).
STORCK, Pierre-Henri; (GB).
STUDLEY, John; (GB).
PIERARD, Francoise, Yvonne Theodora Marie; (GB)
Agent: CHE, Jennifer, G.; Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge, MA 02139 (US)
Priority Data:
61/541,869 30.09.2011 US
61/554,180 01.11.2011 US
61/620,704 05.04.2012 US
Title (EN) COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
(FR) COMPOSÉS UTILES EN TANT QU'INHIBITEURS DE KINASE ATR
Abstract: front page image
(EN)The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I) or a pharmaceutically acceptable salt thereof.
(FR)La présente invention concerne des composés utiles en tant qu'inhibiteurs de protéine kinase ATR. L'invention concerne en outre des compositions pharmaceutiquement acceptables comprenant les composés de cette invention ; des procédés de traitement de traitement de maladies, troubles et affections diverses utilisant les composés de cette invention ; des procédés pour préparer les composés de cette invention ; des intermédiaires pour la préparation des composés de cette invention ; et des procédés d'utilisation des composés dans des applications in vitro, telles que l'étude de kinases dans des phénomènes biologiques et pathologiques ; l'étude de voies de transduction de signal intracellulaire médiées par de telles kinases ; et l'évaluation comparative de nouveaux inhibiteurs de kinase. Le composé de cette invention a la formule (I) ou un sel pharmaceutiquement acceptable de celle-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)