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1. WO2013049595 - METHODS AND COMPOSITIONS OF BILE ACIDS

Publication Number WO/2013/049595
Publication Date 04.04.2013
International Application No. PCT/US2012/057958
International Filing Date 28.09.2012
IPC
A61K 35/413 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
37Digestive system
413Gall bladder; Bile
A61P 1/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
G01N 33/48 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
CPC
A61K 31/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
A61K 35/413
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
37Digestive system
413Gall bladder; Bile
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
Applicants
  • ETHICON ENDO-SURGERY, INC. [US]/[US]
  • THE GENERAL HOSPITAL CORPORATION D/B/A [US]/[US]
Inventors
  • KAPLAN, Lee M.
  • AHMAD, Nadia N.
  • HARRIS, Jason L.
  • FELDER, Kevin D.
  • PASTORELLI, Alessandro
Agents
  • GEARY III, William C.
Priority Data
61/540,95229.09.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS OF BILE ACIDS
(FR) PROCÉDÉS ET COMPOSITIONS D'ACIDES BILIAIRES
Abstract
(EN) Methods and compositions are provided for treating metabolic disorders by modulating bile acid levels. Generally, the methods and compositions can modulate bile acid levels, such as serum bile acid levels, to treat a metabolic disorder. In one embodiment, a method of modulating a bile acid level includes measuring a bile acid level and delivering a composition effective to modulate the bile acid level. A method for modulating a bile acid profile includes comparing a bile acid profile to a target profile and delivering a bile acid cocktail to increase bile acid levels. In another embodiment, a pharmaceutical composition for increasing bile acid levels includes a bile acid cocktail effective to increase bile acid levels. The composition is further useful as part of an implantable system.
(FR) L'invention concerne des procédés et des compositions pour traiter des troubles métaboliques par modulation des taux d'acides biliaires. Les procédés et compositions peuvent moduler les taux d'acides biliaires, notamment les taux d'acides biliaires sériques pour traiter un trouble métabolique. Dans un mode de réalisation, un procédé de modulation du taux d'acides biliaires consiste à mesurer un taux d'acides biliaires et à administrer une composition servant à moduler le taux d'acides biliaires. Un procédé de modulation d'un profil d'acides biliaires consiste à comparer un profil d'acides biliaires à un profil cible et à administrer un cocktail d'acides biliaires. Dans un autre mode de réalisation, une composition pharmaceutique pour augmenter le taux d'acides biliaires contient un cocktail d'acides biliaires servant à augmenter le taux d'acides biliaires. La composition peut par ailleurs faire partie d'un système implantable.
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