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Machine translation
1. (WO2013049559) PYRIDINE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/049559    International Application No.:    PCT/US2012/057899
Publication Date: 04.04.2013 International Filing Date: 28.09.2012
IPC:
C07D 213/30 (2006.01), C07D 213/38 (2006.01), C07D 213/40 (2006.01), C07D 401/06 (2006.01), C07D 405/14 (2006.01), C07D 409/06 (2006.01), C07D 409/14 (2006.01), C07D 413/06 (2006.01), C07D 413/14 (2006.01), C07D 417/06 (2006.01), C07D 417/14 (2006.01), A61K 31/4409 (2006.01), A61K 31/443 (2006.01), A61K 31/4436 (2006.01), A61K 31/4439 (2006.01)
Applicants: ENDO PHARMACEUTICALS INC. [US/US]; 1400 Atwater Drive Malvern, PA 19355 (US)
Inventors: SMITH, Roger, Astbury; (US).
KETHIRI, Raghava, Reddy; (IN).
KRISTAM, Rajendra; (IN).
LAPING, Nicholas, James; (US).
VENKATESHAPPA, Chandregowda; (IN).
KULKARNI, Bheemashankar; (IN).
DEVRAJ, Rajesh; (IN).
DEWANG, Purushottam; (IN).
VENKATESAN, Aranapakam; (IN)
Agent: MURPHY, Glenn, E., J.; RatnerPrestia P.O. Box 980 Valley Forge, PA 19482 (US)
Priority Data:
61/541,621 30.09.2011 US
Title (EN) PYRIDINE DERIVATIVES
(FR) DÉRIVÉS PYRIDINES
Abstract: front page image
(EN)The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP 17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.
(FR)La présente invention concerne de nouveaux composés pyridines et des sels ou promédicaments de qualité pharmaceutique de ceux-ci. L'invention concerne également des procédés de préparation de ces composés. Ces composés sont utiles dans l'inhibition de l'activité CYP 17 par l'administration d'une quantité thérapeutiquement efficace d'un ou de plusieurs des composés à un patient. Ainsi, ces composés sont efficaces dans le traitement d'états associés à une activité CPY17. Divers états peuvent être traités à l'aide de ces composés et comprennent des maladies qui sont caractérisées par une prolifération cellulaire anormale. Dans un mode de réalisation, la maladie est le cancer, tel que le cancer de la prostate.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)