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1. (WO2013049375) METHODS AND COMPOSITIONS FOR MODULATING BETA CELL PROLIFERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/049375    International Application No.:    PCT/US2012/057602
Publication Date: 04.04.2013 International Filing Date: 27.09.2012
IPC:
C12N 5/02 (2006.01), A61P 3/10 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; 1705 El Camino Real Palo Alto, California 94306-1106 (US)
Inventors: CHEN, Hainan; (US).
KIM, Seung, K.; (US)
Agent: ALCAMO, Elizabeth, A.; Bozicevic, Field & Francis LLP 1900 University Avenue, Suite 200 East Palo Alto, CA 94303 (US)
Priority Data:
61/540,524 28.09.2011 US
Title (EN) METHODS AND COMPOSITIONS FOR MODULATING BETA CELL PROLIFERATION
(FR) PROCÉDÉS ET COMPOSITIONS POUR LA MODULATION DE LA PROLIFÉRATION DE CELLULES BÊTA
Abstract: front page image
(EN)Methods and compositions are provided for modulating pancreatic islet β cell proliferation. Aspects of the methods include promoting β cell proliferation by providing agents that promote PDGFR signaling, or inhibiting β cell proliferation by providing agents that inhibit PDGFR signaling. These methods find a number of uses, including, for example, in the treatment of diabetes and human islet diseases. Also provided are reagents and kits thereof that find use in practicing the subject methods.
(FR)L'invention concerne des procédés et compositions pour la modulation de la prolifération de cellules β des îlots du pancréas. Des aspects des procédés comprennent la promotion de la prolifération de cellules β en fournissant des agents qui permettent la signalisation par PDGFR ou l'inhibition de la prolifération de cellules β en fournissant des agents qui inhibent la signalisation par PDGFR. Ces procédés trouvent un nombre d'utilisations, comprenant, par exemple, le traitement du diabète et des maladies des îlots humains. L'invention concerne également des réactifs et des trousses de réactifs qui sont utiles dans la mise en œuvre des procédés de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)