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1. (WO2013049287) CRYSTALLINE HYDROCHLORIDE SALT OF (1- (4 -FLUOROPHENYL) - 1H - INDOL - 5 - YL) - (3- (4- (THIAZOLE - 2 - CARBONYL) PIPERAZIN- 1 - YL) AZ ETIDIN- 1 -YL) METHANONE AND ITS USE IN THE TREATMENT OF PAIN AND METABOLIC DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/049287    International Application No.:    PCT/US2012/057461
Publication Date: 04.04.2013 International Filing Date: 27.09.2012
IPC:
C07D 417/14 (2006.01), A61K 31/496 (2006.01), A61P 29/00 (2006.01), A61P 3/04 (2006.01), A61P 3/10 (2006.01)
Applicants: JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 B-2340 Beerse (BE)
Inventors: BEAUCHAMP, Derek A.; (US).
WELLS, Kenneth M.; (US)
Agent: JOHNSON, Philip S.; Johnson & Johnson One Johnson & Johnson Plaza New Brunswick, New Jersey 08933 (US)
Priority Data:
61/541,281 30.09.2011 US
Title (EN) CRYSTALLINE HYDROCHLORIDE SALT OF (1- (4 -FLUOROPHENYL) - 1H - INDOL - 5 - YL) - (3- (4- (THIAZOLE - 2 - CARBONYL) PIPERAZIN- 1 - YL) AZ ETIDIN- 1 -YL) METHANONE AND ITS USE IN THE TREATMENT OF PAIN AND METABOLIC DISORDERS
(FR) SEL CRISTALLIN DE CHLORHYDRATE DE (1-(4-FLUOROPHÉNYL)-1H-INDOL-5-YL)-(3-(4-(THIAZOLE-2-CARBONYL)PIPÉRAZIN-1-YL)AZÉTIDIN-1-YL)MÉTHANONE ET SON UTILISATION DANS LE TRAITEMENT DE LA DOULEUR ET DE TROUBLES MÉTABOLIQUES
Abstract: front page image
(EN)The present invention relates to a crystalline hydrochloride salt of (l-(4-fluorophenyl)-lH-indol-5-yl)(3-(4-(thiazole-2-carbonyl)piper- azin-l-yl)azetidin-l-yl)methanone, Formula (I) methods of making said salt, pharmaceutical compositions contain¬ ing said salt, and the use of said salt in the treatment of pain and dis¬ eases that cause such pain, and metabolic disorders such as, obesity, hyperphagia, and diabetes.
(FR)La présente invention concerne un sel cristallin de chlorhydrate de (1-(4-fluorophényl)-1H-indol-5-yl)-(3-(4-(thiazole-2-carbonyl)pipérazin-1-yl)azétidin-1-yl)méthanone, formule (I), des procédés de fabrication dudit sel, des compositions pharmaceutiques contenant ledit sel, et l'utilisation dudit sel dans le traitement de la douleur et de maladies qui causent une telle douleur, et de troubles métaboliques tels que l'obésité, l'hyperphagie, et le diabète.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)