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Pub. No.:    WO/2013/049263    International Application No.:    PCT/US2012/057406
Publication Date: 04.04.2013 International Filing Date: 27.09.2012
C07D 495/04 (2006.01), C07D 498/04 (2006.01), A61P 35/00 (2006.01), A61K 31/424 (2006.01), A61K 31/505 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543-4000 (US)
Inventors: BALOG, James Aaron; (US).
HUANG, Audris; (US).
VELAPARTHI, Upender; (US).
LIU, Peiying; (US)
Agent: GREENBLATT, Gary D.; Bristol-Myers Squibb Company P.O. Box 4000 Princeton, New Jersey 08543-4000 (US)
Priority Data:
61/539,570 27.09.2011 US
Abstract: front page image
(EN)Disclosed are azaindazole compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is CH; Z is CR2 or N; Q is a heteroaryl; and R1 is defined herein. Also disclosed are methods of using such compounds in the treatment of at least one CYP17 associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
(FR)La présente invention concerne des composés d'azaindazole de formule (I), ou un de leurs sels pharmaceutiquement acceptables. Dans la formule, X représente O et Y représente N ; ou X représente S et Y représente CH ; Z représente CR2 ou N ; Q représente un hétéroaryle ; et R1 est défini ici. L'invention concerne également des méthodes d'utilisation de tels composés dans le traitement d'au moins un état pathologique associé à CYP17 tel que, par exemple, un cancer, et des compositions pharmaceutiques comprenant de tels composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)