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1. (WO2013049255) SUBSTITUED 5-(PROP-1-YN-1-YL)PICOLINAMIDE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/049255    International Application No.:    PCT/US2012/057395
Publication Date: 04.04.2013 International Filing Date: 26.09.2012
IPC:
A61K 31/497 (2006.01)
Applicants: VANDERBILT UNIVERSITY [US/US]; Center for Technology Transfer and Commercialization 305 Kirkland Hall 2201 West End Avenue Nashville, TN 37240 (US)
Inventors: CONN, P., Jeffrey; (US).
LINDSLEY, Craig, W.; (US).
STAUFFER, Shaun, R.; (US).
ZHOU, Ya; (US).
BARTOLOME-NEBREDA, Jose, Manuel; (ES).
MACDONALD, Gregor, James; (BE).
GOGLIOTTI, Rocco, D.; (US).
TURLINGTON, Mark; (US)
Agent: SHORTELL, D., Brian; Ballard Spahr LLP 999 Peachtree Street Suite 1000 Atlanta, GA 30309 (US)
Priority Data:
61/539,436 26.09.2011 US
Title (EN) SUBSTITUED 5-(PROP-1-YN-1-YL)PICOLINAMIDE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
(FR) ANALOGUES DE 5-(PROP-1-YN-1-YL)PICOLINAMIDE SUBSTITUÉ COMME MODULATEURS ALLOSTÉRIQUES DES RÉCEPTEURS DE MGLUR5
Abstract: front page image
(EN)In one aspect, the invention relates to substituted 5-(prop-1-yn-1-yl)picolinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
(FR)Dans un aspect, l'invention concerne des analogues de 5-(prop-1-yn-1-yl)picolinamide substitué, leurs dérivés et des composés apparentés, qui sont utile comme modulateurs allostériques positifs du récepteur de glutamate métabotrope sous-type 5 (mGluR5) ; des procédés de synthèse pour préparer les composés ; des compositions pharmaceutiques comprenant les composés ; et des procédés de traitement de troubles neurologiques et psychiatriques associés à un dysfonctionnement du glutamate au moyen des composés et compositions. Cet abrégé a pour vocation d'être un outil d'analyse à des fins de recherche dans le domaine particulier et n'est pas destiné à limiter la présente invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)