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1. WO2013048952 - METHODS AND COMPOSITIONS FOR DETECTING INFECTIONS

Publication Number WO/2013/048952
Publication Date 04.04.2013
International Application No. PCT/US2012/056865
International Filing Date 24.09.2012
IPC
C12Q 1/68 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/04
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QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/16
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
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16using radioactive material
C12Q 1/18
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
18Testing for antimicrobial activity of a material
C12Q 1/485
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
48involving transferase
485involving kinase
C12Q 1/689
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
C12Q 1/701
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
70involving virus or bacteriophage
701Specific hybridization probes
Applicants
  • BIOMED VALLEY DISCOVERIES, INC. [US]/[US] (AllExceptUS)
  • SAHA, Saurabh [US]/[US] (US)
  • BETTEGOWDA, Chetan [US]/[US] (US)
  • TUNG, David [US]/[US] (US)
Inventors
  • SAHA, Saurabh
  • BETTEGOWDA, Chetan
  • TUNG, David
Agents
  • HOOPER, Kevin, C.
Priority Data
61/540,15828.09.2011US
61/579,02022.12.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR DETECTING INFECTIONS
(FR) MÉTHODES ET COMPOSITIONS POUR LA DÉTECTION D'INFECTIONS
Abstract
(EN) The present invention provides, inter alia, methods for detecting whether a subject has an infection. These methods include (a) incubating a test sample from a subject suspected of having an infection with a labeled molecule, such as a labeled nucleoside analog, that is preferentially incorporated into a pathogenic microorganism for a period of time sufficient for the pathogenic microorganism to incorporate the labeled molecule; (b) removing any unincorporated labeled molecule from the test sample; and (c) detecting the labeled molecule within the pathogenic microorganism, if any, in the test sample, wherein the presence of labeled molecule within the pathogenic microorganism indicates that the subject has an infection.
(FR) La présente invention concerne, entre autres, des méthodes pour détecter si un sujet présente une infection. Ces méthodes incluent (a) l'incubation d'un échantillon de test provenant d'un sujet suspecté d'avoir une infection avec une molécule marquée, comme un analogue de nucléoside marqué, qui est de préférence incorporé dans un micro-organisme pathogène pendant une période de temps suffisante pour que le micro-organisme pathogène incorpore la molécule marquée; (b) l'élimination de quelconque molécule marquée non incorporée à partir de l'échantillon de test; et (c) la détection de la molécule marquée dans le micro-organisme pathogène, s'il en existe, dans l'échantillon de test, la présence de la molécule marquée dans le micro-organisme pathogène indiquant que le sujet présente une infection.
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