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Pub. No.:    WO/2013/048787    International Application No.:    PCT/US2012/055518
Publication Date: 04.04.2013 International Filing Date: 14.09.2012
A61K 36/28 (2006.01), A61K 36/185 (2006.01), A61K 31/722 (2006.01), A61K 33/00 (2006.01), A61K 35/14 (2006.01), A61L 15/28 (2006.01), A61L 15/22 (2006.01), A61L 15/44 (2006.01), A61P 17/02 (2006.01)
Applicants: YES, INC. [US/US]; 269 S. Beverly Drive, Suite 1171 Beverly Hills, CA 90212 (US) (For All Designated States Except US).
BACCHETTA, Matthew, D. [US/US]; (US) (For US Only).
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; Columbia University Sponsored Projects Finance P.o. Box 1505 New York, NY 10008-1505 (US) (For All Designated States Except US).
EASTWOOD, Linda [US/US]; (US).
SINCLAIR, James, M. [US/US]; (US) (For US Only).
COONS, Harold [US/US]; (US) (For US Only).
SINGH, Gopal [US/US]; (US) (For US Only)
Inventors: BACCHETTA, Matthew, D.; (US).
EASTWOOD, Linda; (US).
SINCLAIR, James, M.; (US).
COONS, Harold; (US).
SINGH, Gopal; (US)
Agent: HUDDLESON, Justin, P.; Choate, Hall & Stewart Llp Two International Place Boston, MA 02110 (US)
Priority Data:
61/539,353 26.09.2011 US
Abstract: front page image
(EN)The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (Chamomilla recutita), the leaves of dioecious nettle (Urtica dioica), kaolin, chitosan, fibrinogen and thrombin. Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with superior and broad spectrum hemostatic capabilities, including the ability to arrest arterial hemorrhage. The invention further provides methods of using the inventive compositions in to reduce or stop bleeding, as well as a variety of apparatuses useful in hemostatic contexts that incorporate the inventive compositions. In one particular embodiment, the invention provides hemostatic dressings in which a polymeric layer incorporating chamomile, nettle, kaolin, chitosan, fibrinogen and thrombin components is applied to a textile or fabric material, for example a non-woven viscose.
(FR)La présente invention concerne des compositions hémostatiques qui comprennent des composants des fleurs de camomille pharmaceutique (Chamomilla recutita), des feuilles d'ortie dioïque (Urtica dioica), du kaolin, du chitosane, du fibrinogène et de la thrombine. En outre, l'inclusion d'une base polymère biocompatible, en particulier d'un alginate, génère une composition présentant des capacités hémostatiques supérieures et à large spectre, y compris la possibilité de stopper une hémorragie artérielle. L'invention concerne également des procédés d'utilisation des compositions de l'invention pour réduire ou stopper un saignement, ainsi qu'une diversité d'appareils utiles dans des contextes hémostatiques qui intègrent les compositions de l'invention. Dans un mode de réalisation particulier, l'invention concerne des pansements hémostatiques dans lesquels une couche polymère incorporant des composants de camomille, d'ortie, de kaolin, de chitosane, de fibrinogène et de thrombine est appliquée sur une matière textile ou un tissu, par exemple une viscose non tissée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)