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Machine translation
1. (WO2013048604) CONTROLLED COVALENT ATTACHMENT OF BIOACTIVE BACTERIOPHAGE FOR REGULATING BIOFILM DEVELOPMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/048604    International Application No.:    PCT/US2012/044707
Publication Date: 04.04.2013 International Filing Date: 28.06.2012
IPC:
A61L 27/52 (2006.01), A61L 27/34 (2006.01), A01N 63/00 (2006.01), A61F 2/00 (2006.01), A61M 25/01 (2006.01), A61F 13/02 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Centers for Disease Control and Prevention Technology Transfer Office 4770 Buford Highway, MS K79 Atlanta, GA 30341 (US) (For All Designated States Except US).
GEORGIA TECH RESEARCH CORPORATION [US/US]; Georgia Institute of Technology 505 Tenth Street, NW Atlanta, GA 30332-0415 (US) (For All Designated States Except US).
DONLAN, Rodney, Martin [US/US]; (US) (For US Only).
LEHMAN, Susan, Marie [CA/US]; (US) (For US Only).
GARCIA, Andres, J. [US/US]; (US) (For US Only)
Inventors: DONLAN, Rodney, Martin; (US).
LEHMAN, Susan, Marie; (US).
GARCIA, Andres, J.; (US)
Agent: GOULD, Weston, R.; Gifford, Krass, Sprinkle, Anderson & Citkowski, PC 2701 Troy Center Drive, Suite 330 Post Office Box 7021 Troy, MI 48007-7021 (US)
Priority Data:
61/501,975 28.06.2011 US
Title (EN) CONTROLLED COVALENT ATTACHMENT OF BIOACTIVE BACTERIOPHAGE FOR REGULATING BIOFILM DEVELOPMENT
(FR) FIXATION COVALENTE CONTRÔLÉE DE BACTÉRIOPHAGE BIOACTIF POUR RÉGULER LE DÉVELOPPEMENT DE BIOFILM
Abstract: front page image
(EN)Medical devices that are resistant to biofilm development and methods of the manufacture of biofilm resistant medical devices are provided. One or more bacteriophages are tethered to the surface of a medical device or a hydrogei-type coating on the surface of the device by covalent bonding while maintaining bacteriophage infective or lytic activity. The presence of the bacteriophages on a medical device, such as an indwelling medical device, prevents biofilm formation or reduces existing biofilm formation on the surface of the device when in use. These devices address the long felt need for biofilm resistant devices that increase safety and reduce complications normally associated with prior indwelling or other medical devices.
(FR)L'invention concerne des dispositifs médicaux qui sont résistant à un développement de biofilm et des procédés de fabrication de dispositifs médicaux résistant au développement d'un biofilm. Un ou plusieurs bactériophages sont attachés à la surface d'un dispositif médical ou à un revêtement de type hydrogel sur la surface du dispositif par liaison covalente tout en maintenant une activité infectante ou lytique de bactériophage. La présence de bactériophages sur un dispositif médical, tel qu'un dispositif médical à demeure, empêche la formation de biofilm ou réduit la formation d'un biofilm existant sur la surface du dispositif lorsqu'il est en utilisation. Ces dispositifs abordent le besoin ressenti depuis longtemps de dispositifs résistant au développement d'un biofilm qui augmentent la sécurité et réduisent les complications normalement associées à des dispositifs médicaux à demeure de l'état de la technique ou à d'autres dispositifs médicaux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)