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1. (WO2013048599) KETOL-ACID REDUCTOISOMERASES WITH IMPROVED PERFORMANCE PROPERTIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/048599    International Application No.:    PCT/US2012/042624
Publication Date: 04.04.2013 International Filing Date: 15.06.2012
IPC:
C12N 1/20 (2006.01), C12P 7/16 (2006.01), C12N 9/90 (2006.01)
Applicants: GEVO, INC. [US/US]; 345 Inverness Drive South Building C Suite 310 Englewood, Colorado 80112 (US) (For All Designated States Except US).
CALIFORNIA INSTITUTE OF TECHNOLOGY [US/US]; 1201 East California Boulevard Pasadena, California 91125 (US) (For All Designated States Except US).
BUELTER, Thomas [DE/US]; (US) (For US Only).
LIES, Douglas [US/US]; (US) (For US Only).
PORTER-SCHEINMAN, Stephanie [US/US]; (US) (For US Only).
SMITH, Christopher [US/US]; (US) (For US Only).
MEINHOLD, Peter [DE/US]; (US) (For US Only).
BERRY, Ruth [US/US]; (US) (For US Only).
SNOW, Christopher [US/US]; (US) (For US Only).
BASTIAN, Sabine [DE/US]; (US) (For All Designated States Except US)
Inventors: BUELTER, Thomas; (US).
LIES, Douglas; (US).
PORTER-SCHEINMAN, Stephanie; (US).
SMITH, Christopher; (US).
MEINHOLD, Peter; (US).
BERRY, Ruth; (US).
SNOW, Christopher; (US)
Agent: BLINKA, Thomas A.; COOLEY LLP 777 6th Street, N.W. Suite 1100 Washington, District of Columbia 20001 (US)
Priority Data:
61/497,851 16.06.2011 US
61/510,617 22.07.2011 US
Title (EN) KETOL-ACID REDUCTOISOMERASES WITH IMPROVED PERFORMANCE PROPERTIES
(FR) RÉDUCTOISOMÉRASES CÉTOL-ACIDE AYANT DES PROPRIÉTÉS DE PERFORMANCE AMÉLIORÉES
Abstract: front page image
(EN)The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof, wherein said KARI is at least about 60% identical to SEQ ID NO: 2. In various aspects of the invention, the recombinant microorganisms may comprise an isobutanol producing metabolic pathway and can be used in methods of making isobutanol.
(FR)La présente invention concerne des microorganismes recombinants comprenant au moins une molécule d'acide nucléique codant pour une réductoisomérase cétol-acide (KARI) ou un variant modifié dépendant de NADH de celle-ci, ladite KARI étant au moins environ à 60 % identique à SEQ ID No:2. Dans divers aspects de l'invention, les microorganismes recombinants peuvent comprendre une voie métabolique de production d'isobutanol et peuvent être utilisés dans des procédés de fabrication d'isobutanol.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)