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1. (WO2013048584) PRODRUGS FOR TREATING MICROBIAL INFECTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/048584    International Application No.:    PCT/US2012/039371
Publication Date: 04.04.2013 International Filing Date: 24.05.2012
IPC:
A61P 31/00 (2006.01)
Applicants: NORTHEASTERN UNIVERSITY [US/US]; 360 Huntington Avenue 960 Renaissance Park Boston, MA 02115-5000 (US) (For All Designated States Except US).
LEWIS, Kim [US/US]; (US) (For US Only).
FLECK, Laura [US/US]; (US) (For US Only).
CASADEI, Gabriele [IT/IT]; (IT) (For US Only)
Inventors: LEWIS, Kim; (US).
FLECK, Laura; (US).
CASADEI, Gabriele; (IT)
Agent: SCOZZAFAVA, Mary Rose; Wilmer Cutler Pickering Hale and Dorr LLP 60 State Street Boston, MA 02109 (US)
Priority Data:
61/489,370 24.05.2011 US
Title (EN) PRODRUGS FOR TREATING MICROBIAL INFECTIONS
(FR) PROMÉDICAMENTS DANS LE TRAITEMENT D'INFECTIONS MICROBIENNES
Abstract: front page image
(EN)Disclosed are methods of inhibiting the growth of pathogens using prodrug compounds as described herein. Also disclosed are methods of treating microbial infections using such compounds. Prodrugs are able to diffuse into the cell where they are converted into a reactive compound by bacterial-specific enzymes. The activated prodrug then covalently binds to multiple targets, creating an irreversible diffusion sink within the cell.
(FR)La présente invention concerne des procédés d'inhibition de la croissance d'agents pathogènes au moyen de composés de promédicaments. L'invention porte également sur des méthodes de traitement d'infections au moyen de ces composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)