WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2013048164) NOVEL COMPOUNDS AS HIF-1αINHIBITORS AND MANUFACTURING PROCESS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/048164    International Application No.:    PCT/KR2012/007876
Publication Date: 04.04.2013 International Filing Date: 27.09.2012
IPC:
C07C 235/18 (2006.01), C07D 241/04 (2006.01), A61K 31/165 (2006.01), A61P 35/00 (2006.01)
Applicants: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 26, Pil-dong 3-ga, Jung-gu Seoul 100-715 (KR).
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 52 Eoeun-dong, Yuseong-gu Daejeon 305-806 (KR)
Inventors: LEE, Kyeong; (KR).
WON, Mi-Sun; (KR).
KIM, Hwan-Mook; (KR).
PARK, Song-Kyu; (KR).
LEE, Ki-Ho; (KR).
LEE, Chang-Woo; (KR).
KIM, Bo-Kyung; (KR).
BAN, Hyun-Seung; (KR).
CHUNG, Kyung-Sook; (KR).
RAVI, Naik; (KR)
Agent: ERUUM PATENT LAW FIRM; 5F., Boseong Bldg. 1005-8, Daechi-dong, Kangnam-gu, Seoul 135-851 (KR)
Priority Data:
10-2011-0097355 27.09.2011 KR
10-2012-0107494 26.09.2012 KR
Title (EN) NOVEL COMPOUNDS AS HIF-1αINHIBITORS AND MANUFACTURING PROCESS THEREOF
(FR) NOUVEAUX COMPOSÉS EN TANT QU'INHIBITEURS DU HIF-1Α, ET LEUR PROCÉDÉ DE FABRICATION
Abstract: front page image
(EN)The present invention relates to novel compounds as HIF-1α inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1α, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1α-mediated VEGFA expression.
(FR)La présente invention concerne de nouveaux composés en tant qu'inhibiteurs du HIF-1α, leur procédé de fabrication, et des compositions pharmaceutiques. Les composés de la présente invention, qui possèdent une activité d'inhibition contre le HIF-1α, peuvent être utilisés dans la prévention thérapeutique et/ou le traitement de divers cancers solides, tels que les cancers du côlon, du foie, de l'estomac et du sein. En outre, les composés de l'invention sont utiles dans le traitement de la rétinopathie diabétique et de l'arthrite rhumatoïde, qui sont aggravées par l'expression VEGFA induite par le HIF-1α.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)