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1. (WO2013047758) CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE HYDRATE, CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE 3/4 HYDRATE, AND METHOD FOR PRODUCING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/047758    International Application No.:    PCT/JP2012/075106
Publication Date: 04.04.2013 International Filing Date: 28.09.2012
IPC:
C07D 233/90 (2006.01), A61K 31/4164 (2006.01), A61P 35/00 (2006.01), C07B 61/00 (2006.01)
Applicants: FUJIFILM CORPORATION [JP/JP]; 26-30, Nishiazabu 2-chome, Minato-ku, Tokyo 1068620 (JP)
Inventors: FUJIMOTO, Taisuke; (JP).
HASHIMOTO, Tomohiro; (JP).
HAYASHI, Katsuyuki; (JP).
TANAKA, Tomoyuki; (JP)
Agent: NAKAJIMA, Jun; TAIYO, NAKAJIMA & KATO, Seventh Floor, HK-Shinjuku Bldg., 3-17, Shinjuku 4-chome, Shinjuku-ku, Tokyo 1600022 (JP)
Priority Data:
2011-213501 28.09.2011 JP
2011-213500 28.09.2011 JP
Title (EN) CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE HYDRATE, CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE 3/4 HYDRATE, AND METHOD FOR PRODUCING SAME
(FR) CRISTAL D'HYDRATE DE 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE, CRISTAL D'HYDRATE 3/4 DE 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE, ET LEUR PROCÉDÉ DE PRODUCTION
(JA) 5-ヒドロキシ-1H-イミダゾール-4-カルボキサミド水和物の結晶及び5-ヒドロキシ-1H-イミダゾール-4-カルボキサミド・3/4水和物の結晶及びその製造方法
Abstract: front page image
(EN)A method for producing 5-hydroxy-1H-imidazole-4-carboxamide 3/4 hydrate, which comprises: a step wherein 2-amino malonamide is reacted with a compound represented by general formula (1) (wherein each R independently represents a C1-3 alkyl group) in the presence of a carboxylic acid so as to obtain 5-hydroxy-1H-imidazole-4-carboxamide; a step wherein the thus-obtained 5-hydroxy-1H-imidazole-4-carboxamide is reacted with an acidic compound so as to obtain an acidic salt of 5-hydroxy-1H-imidazole-4-carboxamide or a hydrate thereof; and a step wherein the thus-obtained acidic salt of 5-hydroxy-1H-imidazole-4-carboxamide or a hydrate thereof is reacted with a salt in the presence of an acidic solvent.
(FR)Cette invention concerne un procédé de production d'hydrate 3/4 de 5-hydroxy-1H-imidazole-4-carboxamide, qui comprend : une étape consistant à faire réagir un 2-aminomalonamide avec un composé représenté par la formule générale (1) (chaque R dans la formule représentant indépendamment un groupe alkyle C1-3) en présence d'un acide carboxylique de façon à obtenir un 5-hydroxy-1H-imidazole-4-carboxamide ; une étape consistant à faire réagir le 5-hydroxy-1H-imidazole-4-carboxamide ainsi obtenu avec un composé acide de façon à obtenir un sel d'acide de 5-hydroxy-1H-imidazole-4-carboxamide ou un hydrate de celui-ci ; et une étape consistant à faire réagir le sel d'acide de 5-hydroxy-1H-imidazole-4-carboxamide ou son hydrate avec un sel en présence d'un solvant acide.
(JA) 2-アミノマロンアミドを、カルボン酸類の存在下、一般式[1] (式中、Rはそれぞれ独立にC1-3アルキル基を示す)で表される化合物と反応させて、5-ヒドロキシ-1H-イミダゾール-4-カルボキサミドを得る工程と、得られた5-ヒドロキシ-1H-イミダゾール-4-カルボキサミドを酸性化合物と反応させて、5-ヒドロキシ-1H-イミダゾール-4-カルボキサミドの酸性塩又はその水和物を得る工程と、得られた5-ヒドロキシ-1H-イミダゾール-4-カルボキサミドの酸性塩又はその水和物を、酸性溶媒の存在下、塩と反応させる工程とを含む5-ヒドロキシ-1H-イミダゾール-4-カルボキサミド・3/4水和物の製造方法である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)