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1. (WO2013046041) PYRIDINYLPYRAZOLES FOR USE AS KINASE MODULATORS FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/046041    International Application No.:    PCT/IB2012/002387
Publication Date: 04.04.2013 International Filing Date: 01.10.2012
IPC:
C07D 401/04 (2006.01), A61K 31/4439 (2006.01), A61P 35/00 (2006.01)
Applicants: SYNOVO GMBH [DE/DE]; Paul-Ehrlich Str. 15 72076 Tubingen (DE)
Inventors: BURNET, Michael, William; (DE).
THAHER, Bassam, Abu; (PS).
EHLERT, Jan; (DE).
KUBBUTAT, Michael; (DE).
SCHAECHTELE, Christoph; (DE).
TOTZKE, Frank; (DE)
Agent: ALTHAUSEN, Sonja; Michalski Hüttermann & Partner Patentanwälte Hafenspitze Speditionstrasse 21 40221 Düsseldorf (DE)
Priority Data:
61/541,648 30.09.2011 US
Title (EN) PYRIDINYLPYRAZOLES FOR USE AS KINASE MODULATORS FOR THE TREATMENT OF CANCER
(FR) PYRIDINYLPYRAZOLES DESTINÉS À ÊTRE UTILISÉS COMME MODULATEURS DE KINASE DANS LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)Compounds of the substituted pyrazole class of Formula (I) as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases is described. Said method is effective and can be provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.
(FR)L'invention concerne des composés de la classe des pyrazoles substitués de formule (I) utiles dans le traitement du cancer. L'invention concerne également une méthode de traitement du cancer dans laquelle un composé inhibe l'activité de kinases associées au récepteur. Ladite méthode est efficace et peut être utilisée en sus des traitements standard, notamment la chimiothérapie à base de médicaments cytotoxiques et d'autres formes d'immunothérapie comprenant des vaccins thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)