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1. (WO2013045380) PHARMACEUTICALLY ACCEPTABLE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND THEIR METHODS OF IDENTIFICATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/045380    International Application No.:    PCT/EP2012/068737
Publication Date: 04.04.2013 International Filing Date: 24.09.2012
Chapter 2 Demand Filed:    22.07.2013    
IPC:
A61K 31/44 (2006.01), A61K 31/4439 (2006.01), A61K 31/4545 (2006.01), A61K 31/497 (2006.01), A61K 31/506 (2006.01), A61K 31/519 (2006.01), A61P 7/00 (2006.01), A61P 9/00 (2006.01), A61P 13/10 (2006.01), A61P 21/00 (2006.01), A61P 25/00 (2006.01), A61P 25/06 (2006.01), A61P 25/14 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
BIEMANS, Barbara [NL/CH]; (CH) (US only).
JAESCHKE, Georg [DE/CH]; (CH) (US only).
LINDEMANN, Lothar [DE/CH]; (CH) (US only).
MUSTER, Wolfgang [DE/DE]; (DE) (US only).
STADLER, Heinz [CH/CH]; (CH) (US only).
VIEIRA, Eric [CH/CH]; (CH) (US only)
Inventors: BIEMANS, Barbara; (CH).
JAESCHKE, Georg; (CH).
LINDEMANN, Lothar; (CH).
MUSTER, Wolfgang; (DE).
STADLER, Heinz; (CH).
VIEIRA, Eric; (CH)
Agent: POPPE, Regina; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
11183570.8 30.09.2011 EP
Title (EN) PHARMACEUTICALLY ACCEPTABLE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND THEIR METHODS OF IDENTIFICATION
(FR) MODULATEURS ALLOSTÉRIQUES POSITIFS DE MGLUR5 PHARMACEUTIQUEMENT ACCEPTABLES ET LEURS PROCÉDÉS D'IDENTIFICATION
Abstract: front page image
(EN)The present invention relates to mGluR5 positive allosteric modulators (PAM) and methods for identifying pharmaceutically acceptable compounds with high tolerability and safety, which method comprises the use of at least one non-competitive mGluR5 allosteric modulator which has a shift factor measured at 10 uM glutamate concentration below 3.0.
(FR)La présente invention concerne des modulateurs allostériques positifs (PAM) de mGluR5 et des procédés d'identification de composés pharmaceutiquement acceptables ayant une haute tolérabilité et innocuité, ce procédé comprenant l'utilisation d'au moins un modulateur allostérique non compétitif de mGluR5 qui présente un facteur de décalage inférieur à 3,0, mesuré à une concentration de glutamate de 10 μM.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)