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1. WO2013044858 - PREPARATION METHOD FOR MEDICAL POROUS METAL IMPLANT MATERIAL

Publication Number WO/2013/044858
Publication Date 04.04.2013
International Application No. PCT/CN2012/082357
International Filing Date 28.09.2012
IPC
C22C 1/08 2006.1
CCHEMISTRY; METALLURGY
22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
CALLOYS
1Making non-ferrous alloys
08Alloys with open or closed pores
C22C 27/02 2006.1
CCHEMISTRY; METALLURGY
22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
CALLOYS
27Alloys based on rhenium or a refractory metal not mentioned in groups C22C14/ or C22C16/130
02Alloys based on vanadium, niobium or tantalum
A61L 27/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
02Inorganic materials
04Metals or alloys
A61L 27/56 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
56Porous or cellular materials
CPC
A61L 2400/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2400Materials characterised by their function or physical properties
08Methods for forming porous structures using a negative form which is filled and then removed by pyrolysis or dissolution
A61L 2430/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
02for reconstruction of bones; weight-bearing implants
A61L 2430/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
12for dental implants or prostheses
A61L 27/047
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
02Inorganic materials
04Metals or alloys
047Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
A61L 27/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
56Porous materials, ; e.g. foams or sponges
B22F 2998/10
BPERFORMING OPERATIONS; TRANSPORTING
22CASTING; POWDER METALLURGY
FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER
2998Supplementary information concerning processes or compositions relating to powder metallurgy
10Processes characterised by the sequence of their steps
Applicants
  • 重庆润泽医药有限公司 CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. [CN]/[CN]
Inventors
  • 叶雷 YE, Lei
Agents
  • 重庆弘旭专利代理有限责任公司 CHONGQING HONGXU PATENT AGENT LTD.
Priority Data
201110296575.929.09.2011CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PREPARATION METHOD FOR MEDICAL POROUS METAL IMPLANT MATERIAL
(FR) PROCÉDÉ DE PRÉPARATION D'UN MATÉRIAU MÉTALLIQUE POREUX POUR IMPLANT MÉDICAL
(ZH) 一种医用多孔金属植入材料的制备方法
Abstract
(EN) A preparation method for a medical porous metal implant material comprising mixing tantalum powder, a pore-forming agent, and a forming agent into a powder mixture, then granulating, injecting into a mold for forming, demolding, degreasing, sintering, and performing a heating process to produce the medical porous metal implant material for dental bone tissue replacement; the pore-forming agent is one or multiple of sodium bicarbonate, urea, sodium chloride, methyl cellulose, and ethyl cellulose, and the forming agent is one or multiple of polyvinyl alcohol, stearic acid, zinc stearate, paraffin, and synthetic rubber; the degreasing process comprises: gradually increasing the temperature to 400 to 800°C at a speed of 0.5 to 3°C/min, introducing argon gas to form a protective atmosphere, and maintaining the temperature for 60 to 240 minutes; the heating process step comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 800 to 900°C at a speed of 10 to 20°C/min, maintaining the temperature for 240 to 480 minutes, cooling to 400°C at a speed of 2 to 5°C/min, maintaining the temperature for 120 to 300 minutes, and cooling together with the furnace to room temperature. The porous tantalum produced is very suitable as a medical implant material for dental bone tissue replacement.
(FR) Procédé de préparation d'un matériau métallique poreux pour implant médical, selon lequel la poudre de tantale est mélangée à un agent de formation de pores et un agent moulant pour obtenir une poudre synthétique granulée, qui sera ensuite injectée dans le moule en vue de son moulage, démoulée, frittée et traitée thermiquement de manière à obtenir un matériau métallique poreux de substitution de tissu osseux dentaire pour implant médical. L'agent de formation de pores représente un ou plusieurs parmi bicarbonate de sodium, urée, chlorure de sodium, métyhlcellulose, éthylcellulose et l'agent moulant est un ou plusieurs parmi alcool polyvinylique, acide stéarique, stéarate de zinc, paraffine et caoutchouc synthétique. L'étape de décrassage s'effectue à une vitesse de 0,5 à 3°C/min afin d'atteindre entre 400 et 800°C de telle sorte que l'argon forme une atmosphère protectrice et conserve la température pendant 60 à 240 min. L'étape de frittage s'effectue à un degré de vide allant de 10-4 Pa à 10-3 Pa avec chauffage de 10 à 20°C/min pour atteindre entre 800 et 900℃ avec préservation de température pendant 240 à 480min, le fourneau se refroidissant jusqu'à atteindre entre 200 et 300°C, puis avec chauffage de 2 à 5℃/min pour atteindre entre 1500 et 400℃ avec préservation de température pendant 120 à 300min. Le matériau de tantale poreux ainsi obtenu, après mesure, satisfait aux exigences d'utilisation d'un matériau pour implant médical de substitution d'un tissu osseux dentaire.
(ZH) 一种医用多孔金属植入材料的制备方法,将钽粉与造孔剂、成型剂混合成混合粉末,再经造粒、注射入模具成型、脱模、脱脂、烧结和热处理制得替代牙骨组织的医用多孔金属植入材料;造孔剂为碳酸氢钠、尿素、氯化钠、甲基纤维素、乙基纤维素中的一种或多种,成型剂为聚乙烯醇、硬脂酸、硬脂酸锌、石蜡、合成橡胶中的一种或多种;所述脱脂过程是以 0.5℃/min~3℃/min 的速率逐步升温至 400~800℃,以氩气通入构成保护气氛并保温 60min~240min;所述热处理步骤是真空度为 10-4Pa~10-3Pa,以 10~20℃/min 升温至 800~900℃、保温 240~480min,再以 2~5℃/min 冷至 400℃、保温 120~300min,然后随炉冷却至室温。制得的多孔钽材料,经过测试非常适合用于作为替代牙骨组织的医用植入材料。
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