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1. WO2013042135 - HETEROARYL COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS

Publication Number WO/2013/042135
Publication Date 28.03.2013
International Application No. PCT/IN2012/000011
International Filing Date 05.01.2012
Chapter 2 Demand Filed 22.08.2012
IPC
C07D 413/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/445 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
A61K 31/4245 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245Oxadiazoles
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61K 31/4245
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
4245Oxadiazoles
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • SUVEN LIFE SCIENCES LIMITED [IN]/[IN] (AllExceptUS)
  • NIROGI, Ramakrishna [IN]/[IN] (UsOnly)
  • MOHAMMED, Abdul Rasheed [IN]/[IN] (UsOnly)
  • YARLAGADDA, Suresh [IN]/[IN] (UsOnly)
  • RAVELLA, Srinivasa Rao [IN]/[IN] (UsOnly)
  • SHINDE, Anil Karbhari [IN]/[IN] (UsOnly)
  • KAMBHAMPATI, Ramasastri [IN]/[IN] (UsOnly)
  • ROAYAPALLEY, Praveen Kumar [IN]/[IN] (UsOnly)
  • JAYARAJAN, Pradeep [IN]/[IN] (UsOnly)
  • BHYRAPUNENI, Gopinadh [IN]/[IN] (UsOnly)
  • PATNALA, Sriramachandra Murthy [IN]/[IN] (UsOnly)
  • RAVULA, Jyothsna [IN]/[IN] (UsOnly)
  • JASTI, Venkateswarlu [US]/[IN] (UsOnly)
Inventors
  • NIROGI, Ramakrishna
  • MOHAMMED, Abdul Rasheed
  • YARLAGADDA, Suresh
  • RAVELLA, Srinivasa Rao
  • SHINDE, Anil Karbhari
  • KAMBHAMPATI, Ramasastri
  • ROAYAPALLEY, Praveen Kumar
  • JAYARAJAN, Pradeep
  • BHYRAPUNENI, Gopinadh
  • PATNALA, Sriramachandra Murthy
  • RAVULA, Jyothsna
  • JASTI, Venkateswarlu
Agents
  • SUBRAMANIAM, Hariharan
Priority Data
3203/CHE/201119.09.2011IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HETEROARYL COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS
(FR) COMPOSÉS HÉTÉROARYLES CONVENANT COMME LIGANDS DU RÉCEPTEUR 5-HT4
Abstract
(EN) The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HT4 receptors.
(FR) La présente invention concerne, d'une part de nouveaux composés représentés par la formule (I), d'autre part leurs sels pharmaceutiquement admis, et enfin des compositions les contenant. L'invention concerne également un procédé d'élaboration de ces composés et de leurs sels pharmaceutiquement admis. Les composés représentés par la formule (I) conviennent au traitement de divers troubles dans lesquels interviennent les récepteurs 5-HT4.
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