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1. WO2013041457 - N-PIPERIDIN-4-YL DERIVATIVES

Publication Number WO/2013/041457
Publication Date 28.03.2013
International Application No. PCT/EP2012/068070
International Filing Date 14.09.2012
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
06
of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C07D 401/04 (2006.01)
C07D 401/14 (2006.01)
C07D 405/14 (2006.01)
C07D 413/14 (2006.01)
A61K 31/506 (2006.01)
A61P 5/06 (2006.01)
CPC
C07D 401/04
C07D 401/14
C07D 405/14
C07D 413/14
C07D 417/14
Applicants
  • MERCK SHARP & DOHME B.V. [NL/NL]; Waardeweg 39 NL-2031 BN Haarlem, NL (AllExceptUS)
  • HUISMAN, Ines [NL/NL]; NL (UsOnly)
  • VAN DER STELT, Marcelis [NL/NL]; NL (UsOnly)
  • WIEDENHOF, Wouter [NL/NL]; NL (UsOnly)
  • BAKER-GLENN, Charles, Anthony, Graham [GB/GB]; GB (UsOnly)
  • BLACKABY, Wesley, Peter [GB/GB]; GB (UsOnly)
  • TRIVEDI, Naimisha [GB/GB]; GB (UsOnly)
Inventors
  • HUISMAN, Ines; NL
  • VAN DER STELT, Marcelis; NL
  • WIEDENHOF, Wouter; NL
  • BAKER-GLENN, Charles, Anthony, Graham; GB
  • BLACKABY, Wesley, Peter; GB
  • TRIVEDI, Naimisha; GB
Agents
  • JAAP, David, Robert; Merck Sharp & Dohme Ltd Hertford Road Hoddesdon Hertfordshire EN11 9BU, GB
Priority Data
11182282.122.09.2011EP
61/537,68922.09.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) N-PIPERIDIN-4-YL DERIVATIVES
(FR) DÉRIVÉS DE N-PIPÉRIDINE-4-YL
Abstract
(EN)
The invention relates to a N-piperidin-4-yl derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same and to the use of said N-piperidin-4-yl derivatives for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, or for the treatment of uterine fibroids or other menstrual-related disorders.
(FR)
La présente invention concerne un dérivé de N-pipéridine-4-yl ayant la formule générale I ou un sel pharmaceutiquement acceptable de celui-ci, des compositions pharmaceutiques le comprenant et l'utilisation desdits dérivés de N-pipéridine-4-yl pour le traitement et la prévention de l'endométriose, pour le traitement et la prévention du cancer du sein hormonodépendant pré-ménopause et péri-ménopause, pour la contraception, ou pour le traitement de fibromyomes ou d'autres troubles liés à la menstruation.
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