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1. WO2013041457 - N-PIPERIDIN-4-YL DERIVATIVES

Publication Number WO/2013/041457
Publication Date 28.03.2013
International Application No. PCT/EP2012/068070
International Filing Date 14.09.2012
IPC
C07D 401/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 405/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 413/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/506 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61P 5/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
06of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
CPC
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 5/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
06of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
Applicants
  • MERCK SHARP & DOHME B.V. [NL]/[NL] (AllExceptUS)
  • HUISMAN, Ines [NL]/[NL] (UsOnly)
  • VAN DER STELT, Marcelis [NL]/[NL] (UsOnly)
  • WIEDENHOF, Wouter [NL]/[NL] (UsOnly)
  • BAKER-GLENN, Charles, Anthony, Graham [GB]/[GB] (UsOnly)
  • BLACKABY, Wesley, Peter [GB]/[GB] (UsOnly)
  • TRIVEDI, Naimisha [GB]/[GB] (UsOnly)
Inventors
  • HUISMAN, Ines
  • VAN DER STELT, Marcelis
  • WIEDENHOF, Wouter
  • BAKER-GLENN, Charles, Anthony, Graham
  • BLACKABY, Wesley, Peter
  • TRIVEDI, Naimisha
Agents
  • JAAP, David, Robert
Priority Data
11182282.122.09.2011EP
61/537,68922.09.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) N-PIPERIDIN-4-YL DERIVATIVES
(FR) DÉRIVÉS DE N-PIPÉRIDINE-4-YL
Abstract
(EN) The invention relates to a N-piperidin-4-yl derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same and to the use of said N-piperidin-4-yl derivatives for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, or for the treatment of uterine fibroids or other menstrual-related disorders.
(FR) La présente invention concerne un dérivé de N-pipéridine-4-yl ayant la formule générale I ou un sel pharmaceutiquement acceptable de celui-ci, des compositions pharmaceutiques le comprenant et l'utilisation desdits dérivés de N-pipéridine-4-yl pour le traitement et la prévention de l'endométriose, pour le traitement et la prévention du cancer du sein hormonodépendant pré-ménopause et péri-ménopause, pour la contraception, ou pour le traitement de fibromyomes ou d'autres troubles liés à la menstruation.
Latest bibliographic data on file with the International Bureau