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1. WO2013037809 - TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES AS HUMAN NEUTROPHIL ELASTASE INHIBITORS

Publication Number WO/2013/037809
Publication Date 21.03.2013
International Application No. PCT/EP2012/067810
International Filing Date 12.09.2012
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • CHIESI FARMACEUTICI S.p.A. [IT]/[IT] (AllExceptUS)
  • BLENCH, Toby Jonathan [GB]/[IT] (UsOnly)
  • EDWARDS, Christine [GB]/[IT] (UsOnly)
  • HEALD, Robert Andrew [GB]/[IT] (UsOnly)
  • KULAGOWSKI, Janusz Jozef [GB]/[IT] (UsOnly)
  • SUTTON, Jonathan Mark [GB]/[IT] (UsOnly)
  • CAPALDI, Carmelida [IT]/[IT] (UsOnly)
Inventors
  • BLENCH, Toby Jonathan
  • EDWARDS, Christine
  • HEALD, Robert Andrew
  • KULAGOWSKI, Janusz Jozef
  • SUTTON, Jonathan Mark
  • CAPALDI, Carmelida
Agents
  • MINOJA, Fabrizio
Priority Data
11181201.214.09.2011EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
(FR) DÉRIVÉS DE TÉTRAHYDROTRIAZOLOPYRIMIDINE EN TANT QU'INHIBITEURS DE LA NEUTROPHILE ÉLASTASE HUMAINE
Abstract
(EN) Compounds of formula (I) are inhibitors of human neutrophil elastase.
(FR) La présente invention concerne des composés de formule (I), qui sont des inhibiteurs de la neutrophile élastase humaine.
Latest bibliographic data on file with the International Bureau