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1. (WO2013033901) HETEROCYCLIC-SUBSTITUTED BENZOFURAN DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2013/033901 International Application No.: PCT/CN2011/079467
Publication Date: 14.03.2013 International Filing Date: 08.09.2011
IPC:
C07D 407/14 (2006.01) ,C07D 493/00 (2006.01) ,A61K 31/343 (2006.01) ,A61K 31/14 (2006.01) ,A61P 31/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
407
Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343
condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
14
Quaternary ammonium compounds, e.g. edrophonium, choline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
Applicants:
MERCK SHARP & DOHME CORP. [US/US]; 126 E. Lincoln Avenue Rahway, New Jersey 07065, US (AllExceptUS)
MCCOMAS, Casey Cameron [US/US]; US (UsOnly)
LIVERTON, Nigel J. [GB/US]; US (UsOnly)
HABERMANN, Joerg [DE/IT]; IT (UsOnly)
KOCH, Uwe [DE/IT]; IT (UsOnly)
NARJES, Frank [DE/IT]; IT (UsOnly)
LI, Peng [CN/CN]; CN (UsOnly)
PENG, Xuanjia [CN/CN]; CN (UsOnly)
SOLL, Richard [US/CN]; CN (UsOnly)
WU, Hao [CN/CN]; CN (UsOnly)
Inventors:
MCCOMAS, Casey Cameron; US
LIVERTON, Nigel J.; US
HABERMANN, Joerg; IT
KOCH, Uwe; IT
NARJES, Frank; IT
LI, Peng; CN
PENG, Xuanjia; CN
SOLL, Richard; CN
WU, Hao; CN
Agent:
LIU, SHEN & ASSOCIATES; A0601, Huibin Building No.8 Beichen Dong Street, Chaoyang District Beijing 100101, CN
Priority Data:
Title (EN) HETEROCYCLIC-SUBSTITUTED BENZOFURAN DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
(FR) DÉRIVÉS BENZOFURANES SUBSTITUÉS PAR UN HÉTÉROCYCLE ET LEURS PROCÉDÉS D'UTILISATION POUR LE TRAITEMENT DE MALADIES VIRALES
Abstract:
(EN) The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
(FR) La présente invention concerne des composés de formule (I) qui sont utiles en tant qu'inhibiteurs de la polymérase NS5B du virus de l'hépatite C (VHC), la synthèse de tels composés, et l'utilisation de tels composés pour l'inhibition de l'activité polymérase NS5B du VHC, pour le traitement ou la prévention d'infections par le VHC et pour l'inhibition de la réplication virale du VHC et/ou de la production virale de VHC dans un système cellulaire.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)