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1. WO2013029181 - METHOD AND SYSTEM FOR ABO ANTIBODY DETECTION AND CHARACTERIZATION

Publication Number WO/2013/029181
Publication Date 07.03.2013
International Application No. PCT/CA2012/050602
International Filing Date 30.08.2012
IPC
G01N 33/80 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
80involving blood groups or blood types
C40B 30/04 2006.1
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
04by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
C40B 40/12 2006.1
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
12Libraries containing saccharides or polysaccharides, or derivatives thereof
G01N 33/564 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
564for pre-existing immune complex or autoimmune disease
CPC
G01N 2400/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2400Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
G01N 33/66
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
66involving blood sugars, e.g. galactose
G01N 33/6854
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6854Immunoglobulins
G01N 33/80
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
80involving blood groups or blood types ; or red blood cells
Applicants
  • THE GOVERNORS OF THE UNIVERSITY OF ALBERTA [CA]/[CA] (AllExceptUS)
  • LOWARY, Todd Lambert [CA]/[CA] (UsOnly)
  • CAIRO, Christopher Warren [US]/[CA] (UsOnly)
  • WEST, Lori Jeanne [CA]/[CA] (UsOnly)
  • BURIAK, Jillian Mary [CA]/[CA] (UsOnly)
  • MELONCELLI, Peter John [AU]/[CA] (UsOnly)
  • JEYAKANTHAN, Mylvaganam [GB]/[CA] (UsOnly)
  • SLANEY, Anne Margaret [CA]/[CA] (UsOnly)
Inventors
  • LOWARY, Todd Lambert
  • CAIRO, Christopher Warren
  • WEST, Lori Jeanne
  • BURIAK, Jillian Mary
  • MELONCELLI, Peter John
  • JEYAKANTHAN, Mylvaganam
  • SLANEY, Anne Margaret
Agents
  • OSLER, HOSKIN & HARCOURT LLP
Priority Data
61/529,08230.08.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD AND SYSTEM FOR ABO ANTIBODY DETECTION AND CHARACTERIZATION
(FR) PROCÉDÉ ET SYSTÈME DE DÉTECTION ET DE CARACTÉRISATION D'ANTICORPS ABO
Abstract
(EN) The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO-incompatible and ABO- compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo- blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo-blood subgroup, the determined antibody profile is compared to known ABO histo- blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject. Profiles can be established by applying a sample to an array of surface-bound ABO antigens selected from the group of type I to type VI antigens of each blood group A, B or H.
(FR) La présente invention concerne un système et un procédé de détection et de caractérisation d'anticorps ABO, permettant d'évaluer et de gérer d'une autre manière les greffons ABO-incompatible et ABO-compatible. Le procédé et le système comprennent la détermination d'un profil d'anticorps anti-ABO dirigés contre des sous-types d'antigènes érythrocytaires d'un patient au moyen d'un échantillon biologique prélevé sur le patient. Le procédé et le système peuvent être utilisés pour évaluer la compatibilité d'un produit sanguin ou tissulaire d'un donneur avec un patient receveur, en effectuant une comparaison entre le profil déterminé d'anticorps anti-ABO dirigés contre des sous-types d'antigènes du patient receveur et le groupe sanguin tissulaire ABO ou le sous-groupe sanguin tissulaire ABO d'un produit sanguin ou tissulaire d'un donneur. Afin de définir le sous-groupe sanguin tissulaire ABO du patient, le profil d'anticorps déterminé est comparé à des profils connus de sous-types d'antigènes de groupe sanguin tissulaire ABO et/ou à des profils connus d'anticorps anti-ABO dirigés contre des sous-types d'antigènes pour des sous-groupes sanguins tissulaires ABO afin d'identifier le sous-groupe sanguin tissulaire ABO du patient. Les profils peuvent être établis en appliquant un échantillon sur un réseau d'antigènes ABO liés en surface choisis parmi les antigènes de type I à VI de chaque groupe sanguin A, B ou H.
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