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1. WO2013028756 - ATOM TRANSFER RADICAL POLYMERIZATION UNDER BIOLOGICALLY COMPATIBLE CONDITIONS

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Publication Number WO/2013/028756
Publication Date 28.02.2013
International Application No. PCT/US2012/051855
International Filing Date 22.08.2012
IPC
A61K 9/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
CPC
A61K 47/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C07K 1/1077
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
107by chemical modification of precursor peptides
1072by covalent attachment of residues or functional groups
1077by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
C07K 14/43595
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
43595from coelenteratae, e.g. medusae
C07K 14/765
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
76Albumins
765Serum albumin, e.g. HSA
C08F 283/06
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
283Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
06on to polyethers, polyoxymethylenes or polyacetals
C08F 289/00
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
289Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
Applicants
  • CARNEGIE MELLON UNIVERSITY [US]/[US] (AllExceptUS)
  • MATYJASZEWSKI, Krzysztof [US]/[US] (UsOnly)
  • AVERICK, Saadyah, E. [US]/[US] (UsOnly)
  • SIMAKOVA, Antonina [RU]/[US] (UsOnly)
Inventors
  • MATYJASZEWSKI, Krzysztof
  • AVERICK, Saadyah, E.
  • SIMAKOVA, Antonina
Agents
  • KENT, Joseph, L.
Priority Data
61/575,48222.08.2011US
61/690,68802.07.2012US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ATOM TRANSFER RADICAL POLYMERIZATION UNDER BIOLOGICALLY COMPATIBLE CONDITIONS
(FR) POLYMÉRISATION RADICALAIRE PAR TRANSFERT D'ATOMES DANS DES CONDITIONS COMPATIBLES DU POINT DE VUE BIOLOGIQUE
Abstract
(EN) Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The methods provide biomolecule-polymer conjugates with highly controlled structures and narrow polydispersities under aqueous reaction conditions and biological temperatures. Biomolecules, such as proteins and nucleotides can be conjugated to polymers with high levels of control.
(FR) La présente invention concerne des procédés de mise en œuvre de polymérisations radicalaires sous une forme de greffage contrôlé à partir de molécules biologiques dans des conditions qui sont compatibles du point de vue biologique. Les procédés de l'invention mènent à des conjugués polymères-molécules biologiques ayant des structures hautement contrôlées et des polydispersités étroites dans des conditions aqueuses de réaction et des températures biologiques. Des molécules biologiques, telles que des protéines et des nucléotides, peuvent être conjuguées à des polymères avec des niveaux de contrôle élevés.
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