WO2013026099 FN14 BINDING PROTEINS AND USES THEREOF

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Publication Number WO/2013/026099

Publication Date 28.02.2013

International Application No. PCT/AU2012/000989

International Filing Date 23.08.2012

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Applicants

TRANSBIO LTD [AU]/[AU] (AllExceptUS)
HOOGENRAAD, Nicholas Johannes [AU]/[AU] (UsOnly)
JOHNSTON, Amelia Jane [AU]/[AU] (UsOnly)
SILKE, John [GB]/[AU] (UsOnly)

Inventors

HOOGENRAAD, Nicholas Johannes
JOHNSTON, Amelia Jane
SILKE, John

Agents

FB RICE

Priority Data

61/526,599

23.08.2011

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) FN14 BINDING PROTEINS AND USES THEREOF

(FR) PROTÉINES DE LIAISON À FN14 ET LEURS UTILISATIONS

Abstract

(EN) The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.

(FR) La présente invention concerne des protéines comprenant des domaines de liaison à un antigène d'un anticorps, qui se lient à Fn14, et leurs utilisations. La présente invention concerne également des méthodes de traitement de troubles cachectiques, tels que la cachexie.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants
30	from tumour cells

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
395	Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21	Drugs for disorders of the muscular or neuromuscular system

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3	Drugs for disorders of the metabolism
08	for glucose homeostasis
10	for hyperglycaemia, e.g. antidiabetics

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1. WO2013026099 - FN14 BINDING PROTEINS AND USES THEREOF

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
20	characterized by taxonomic origin
24	containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
33	Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
34	Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
50	characterized by immunoglobulin fragments
55	Fab or Fab'