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1. (WO2013018891) PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2013/018891 International Application No.: PCT/JP2012/069853
Publication Date: 07.02.2013 International Filing Date: 03.08.2012
IPC:
C12N 15/09 (2006.01) ,A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01) ,C07K 16/30 (2006.01) ,C12P 21/08 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
Applicants:
東レ株式会社 TORAY INDUSTRIES, INC. [JP/JP]; 東京都中央区日本橋室町2丁目1番1号 1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666, JP (AllExceptUS)
岡野 文義 OKANO Fumiyoshi [JP/JP]; JP (UsOnly)
小林 真一 KOBAYASHI Shinichi [JP/JP]; JP (UsOnly)
南田 佳孝 MINAMIDA Yoshitaka [JP/JP]; JP (UsOnly)
齋藤 孝則 SAITO Takanori [JP/JP]; JP (UsOnly)
Inventors:
岡野 文義 OKANO Fumiyoshi; JP
小林 真一 KOBAYASHI Shinichi; JP
南田 佳孝 MINAMIDA Yoshitaka; JP
齋藤 孝則 SAITO Takanori; JP
Agent:
平木 祐輔 HIRAKI Yusuke; 東京都港区愛宕2丁目5番1号 愛宕グリーンヒルズMORIタワー32階 Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232, JP
Priority Data:
2011-17137704.08.2011JP
Title (EN) PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER
(FR) COMPOSITION PHARMACEUTIQUE DESTINÉE À TRAITER OU À PRÉVENIR LE CANCER
(JA) 癌の治療及び/又は予防用医薬組成物
Abstract:
(EN) The purpose of the present invention is to produce an antibody having higher antitumor activity than conventional antibodies that target CAPRIN-1, which is specifically expressed on the surface of a cancer cell, and to provide the use of the antibody as an agent for the treatment and/or prophylaxis of cancer. The present invention provides the use, as an agent for the treatment and/or prophylaxis of cancer, of an antibody that identifies and targets a cancer antigen protein that is specifically expressed on the surface of a cancer cell. More specifically, the present invention provides a pharmaceutical composition for the treatment and/or prophylaxis of cancer, the pharmaceutical composition being characterized by containing, as an active ingredient: an antibody that has immunological reactivity with CAPRIN-1 protein and that comprises a heavy-chain variable region including amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light-chain variable region including amino acid sequences represented by SEQ ID NOs: 9, 10, and 11; or a fragment of said antibody.
(FR) L'objet de cette invention est de produire un anticorps ayant une activité antitumorale plus élevée que les anticorps classiques qui ciblent CAPRIN-1, une protéine spécifiquement exprimée à la surface d'une cellule cancéreuse, et d'utiliser ledit anticorps à titre d'agent pour traiter et/ou prévenir le cancer. Cette invention concerne l'utilisation, à titre d'agent destiné à traiter et/ou à prévenir le cancer, d'un anticorps qui identifie et cible une protéine antigénique du cancer qui est spécifiquement exprimée à la surface d'une cellule cancéreuse. Plus spécifiquement, cette invention concerne une composition pharmaceutique destinée à traiter ou à prévenir le cancer, ladite composition pharmaceutique étant caractérisée en ce qu'elle contient, à titre de principe actif : un anticorps ayant une réactivité immunologique avec la protéine CAPRIN-1 et qui comprend une région variable de chaîne lourde contenant les séquences d'acides aminés représentées par SEQ ID Nos : 5, 6, et 7 et une région variable de chaîne légère contenant les séquences d'acides aminés représentées par SEQ ID Nos : 9, 10, et 11 ; ou un fragment dudit anticorps.
(JA)  癌細胞の表面に特異的に発現するCAPRIN-1を標的とした従来の抗体よりも抗腫瘍活性の優れた抗体を作出し、癌の治療及び/又は予防剤としての用途を提供することを目的とする。 癌細胞の表面に特異的に発現する癌抗原タンパク質を同定し、それを標的とした抗体の、癌の治療及び/又は予防剤としての用途、具体的には、配列番号5、6及び7に示すアミノ酸配列を含む重鎖可変領域と配列番号9、10及び11に示すアミノ酸配列を含む軽鎖可変領域とを含み、かつ、CAPRIN-1タンパク質と免疫学的反応性を有する抗体又はそのフラグメントを有効成分として含むことを特徴とする、癌の治療及び/又は予防のための医薬組成物を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
CA2844040CN103717739EP2740794US20140154261JPWO2013018891KR1020140054180
RU2014108043AU2012290954RU0002610428BR112014002613JP6065590IN288/KOLNP/2014
DK2740794PT2740794