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1. (WO2013017724) USE OF A COMBINATION OF AZATHIOPRINE AND L-BUTHIONINE-[S,R]-SULFOXIMINE IN THE PREPARATION OF A DRUG USEFUL IN THE TREATMENT OF A REFRACTORY TUMOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2013/017724 International Application No.: PCT/ES2012/070593
Publication Date: 07.02.2013 International Filing Date: 30.07.2012
IPC:
A61K 31/52 (2006.01) ,A61K 31/198 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
UNIVERSIDAD DE ALCALÁ [ES/ES]; Plaza de San Diego E-28801 Alcala de Henares, ES (AllExceptUS)
UNIVERSIDAD AUTÓNOMA DE MADRID [ES/ES]; Ciudad Universitaria Cantoblanco C/ Einstein, 3. E-28049 Madrid, ES (AllExceptUS)
GONZÁLEZ GUIJARRO, Luis [ES/ES]; ES (UsOnly)
HERNÁNDEZ-BREIJO, Borja [ES/ES]; ES (UsOnly)
ROMÁN CURTO, Irene de los Dolores [ES/ES]; ES (UsOnly)
FERNÁNDEZ MORENO, María de los Dolores [ES/ES]; ES (UsOnly)
PÉREZ GISBERT, Javier [ES/ES]; ES (UsOnly)
Inventors:
GONZÁLEZ GUIJARRO, Luis; ES
HERNÁNDEZ-BREIJO, Borja; ES
ROMÁN CURTO, Irene de los Dolores; ES
FERNÁNDEZ MORENO, María de los Dolores; ES
PÉREZ GISBERT, Javier; ES
Agent:
CARVAJAL Y URQUIJO, Isabel; Goya 11 E-28001 Madrid, ES
Priority Data:
P20113131529.07.2011ES
Title (EN) USE OF A COMBINATION OF AZATHIOPRINE AND L-BUTHIONINE-[S,R]-SULFOXIMINE IN THE PREPARATION OF A DRUG USEFUL IN THE TREATMENT OF A REFRACTORY TUMOR
(ES) USO DE UNA COMBINACIÓN DE AZATIOPRINA Y L-BUTIONINA-[S,R]-SULFOXIMINA EN LA PREPARACIÓN DE UN MEDICAMENTO ÚTIL PARA EL TRATAMIENTO DE UN TUMOR REFRACTARIO
(FR) UTILISATION D'UNE COMBINAISON D'AZATHIOPRINE ET DE L-BUTIONINE-[S,R]-SULFOXIMINE DANS LA PRÉPARATION D'UN MÉDICAMENT UTILE POUR LE TRAITEMENT D'UNE TUMEUR RÉFRACTAIRE
Abstract:
(EN) The present invention relates to the use of a combination of azathioprine (AZA) and L- buthionine-[S,R]-sulfoximine (BSO), or the pharmaceutically suitable salts thereof, in the preparation of a drug useful in the treatment of a refractory tumor, preferably cancer. The combination in the invention has been shown to be especially effective, in particular in the treatment of solid tumors of the liver, colon and colon metastasis to the liver, tumors that are highly resistant to chemotherapy. The invention likewise relates to the pharmaceutical composition containing the combination and to the kit containing same.
(ES) La presente invención describe el uso de una combinación de azatioprina (AZA) y L- butionina-[S,R]-sulfoximina (BSO), o sus sales farmacéuticamente aceptables, en la preparación de un medicamento útil para el tratamiento de un tumor refractario, preferiblemente cáncer. La combinación de la invención se ha mostrado como especialmente eficiente respecto de la técnica en particular en el tratamiento de tumores sólidos de hígado, de colon y de metástasis de colon en el hígado, tumores que presentan gran resistencia a la quimioterapia. La invención también protege la composición farmacéutica en la que se presenta la combinación y el kit que contiene
(FR) La présente invention concerne l'utilisation d'une combinaison d'azathioprine (AZA) et de L-butionine-[S,R]-sulfoximine (BSO), ou de leurs sels pharmaceutiquement acceptables, dans la préparation d'un médicament utile pour le traitement d'une tumeur réfractaire, de préférence un cancer. La combinaison de l'invention s'est révélée particulièrement efficace par rapport à la technique antérieure, notamment dans le traitement de tumeurs solides du foie et du côlon et de la métastase du côlon dans le foie, tumeurs présentant une haute résistance à la chimiothérapie. L'invention concerne également une composition pharmaceutique renfermant cette combinaison et une trousse contenant ladite composition.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)