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1. WO2013016144 - COMPOSITIONS COMPRISING POMEGRANATE POLYPHENOLS IN COMBINATION WITH ERECTILE DYSFUNCTION-TREATING COMPOUNDS, AND METHODS OF TREATING ERECTILE DYSFUNCTION THEREWITH

Publication Number WO/2013/016144
Publication Date 31.01.2013
International Application No. PCT/US2012/047461
International Filing Date 19.07.2012
IPC
A61P 15/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders; Contraceptives
10for impotence
CPC
A61K 31/366
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
A61K 31/4985
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 31/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
53having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 36/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
Applicants
  • POM WONDERFUL, LLC [US]/[US] (AllExceptUS)
  • GILLESPIE, Bradley, K. [US]/[US] (UsOnly)
Inventors
  • GILLESPIE, Bradley, K.
Agents
  • LEITH, Nancy, J.
Priority Data
61/510,83722.07.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS COMPRISING POMEGRANATE POLYPHENOLS IN COMBINATION WITH ERECTILE DYSFUNCTION-TREATING COMPOUNDS, AND METHODS OF TREATING ERECTILE DYSFUNCTION THEREWITH
(FR) COMPOSITIONS COMPRENANT DES POLYPHÉNOLS DE GRENADE EN COMBINAISON AVEC DES COMPOSÉS DE TRAITEMENT DE LA DYSÉRECTION, ET PROCÉDÉ DE TRAITEMENT DE LA DYSÉRECTION À L'AIDE DE CELLE-CI
Abstract
(EN)
The invention relates to compositions comprising a mixture of a pomegranate extract and an erectile dysfunction-treating compound. These compositions can be used to treat erectile dysfunction in men and sexual dysfunction in women. The pomegranate extract and the erectile dysfunction-treating compounds surprisingly and unexpectedly act in a synergistic manner, allowing the compositions to contain a lower amount of the pomegranate extract, the erectile dysfunction-treating compound, or both. The synergism of the two components of the composition results in a lower incident of side effects, as well as being less expensive. The invention also relates to products comprising a series of dosages of the compositions of the invention, wherein either the pomegranate extract or erectile dysfunction-treating compound can be raised or lowered, until a maintenance dosage level of the pomegranate extract and the erectile dysfunction-treating compound is reached.
(FR)
L'invention concerne des compositions comprenant un mélange d'un extrait de grenade et d'un composé de traitement de la dysérection. Ces compositions peuvent être utilisées pour traiter la dysérection chez les hommes et le dysfonctionnement sexuel chez les femmes. L'extrait de grenade et les composés de traitement de la dysérection agissent de manière surprenante et inattendue d'une manière synergique, permettant aux compositions de contenir une quantité inférieure de l'extrait de grenade, du composé de traitement de la dysérection, ou des deux. La synergie des deux composants de la composition conduit à une incidence inférieure d'effets secondaires, ainsi qu'à une réduction des coûts. L'invention concerne également des produits comprenant une série de dosages des compositions de l'invention, où soit l'extrait de grenade soit le composé de traitement de la dysérection peut être augmenté ou abaissé, jusqu'à ce qu'un niveau de dosage d'entretien de l'extrait de grenade et du composé de traitement de la dysérection soit atteint.
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