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1. WO2013010904 - NOVEL SUBSTITUTED INDOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

Publication Number WO/2013/010904
Publication Date 24.01.2013
International Application No. PCT/EP2012/063667
International Filing Date 12.07.2012
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 498/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/5383 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5383ortho- or peri-condensed with heterocyclic ring systems
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 498/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • JANSSEN PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • CELLZOME LIMITED [GB]/[GB] (AllExceptUS)
  • MINNE, Garrett, Berlond [BE]/[BE] (UsOnly)
  • BISCHOFF, François Paul [FR]/[BE] (UsOnly)
  • GIJSEN, Henricus, Jacobus, Maria [NL]/[NL] (UsOnly)
  • VELTER, Adriana, Ingrid [RO]/[BE] (UsOnly)
  • PIETERS, Serge, Maria, Aloysius [NL]/[NL] (UsOnly)
  • BERTHELOT, Didier, Jean-Claude [FR]/[BE] (UsOnly)
Inventors
  • MINNE, Garrett, Berlond
  • BISCHOFF, François Paul
  • GIJSEN, Henricus, Jacobus, Maria
  • VELTER, Adriana, Ingrid
  • PIETERS, Serge, Maria, Aloysius
  • BERTHELOT, Didier, Jean-Claude
Agents
  • QUAGHEBEUR, Luc
Priority Data
11174120.315.07.2011EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL SUBSTITUTED INDOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
(FR) NOUVEAUX DÉRIVÉS D'INDOLE SUBSTITUÉS UTILISÉS EN TANT QUE MODULATEURS DE LA GAMMA-SÉCRÉTASE
Abstract
(EN)
The present invention is concerned with novel substituted indole derivatives of Formula (I) wherein R1, R2, R3, A1, A2, A3, Y and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
(FR)
L'invention concerne de nouveaux dérivés d'indole substitués représentés par la formule (I), dans laquelle R1, R2, R3, A1, A2, A3, Y et X ont la signification définie dans les revendications. Les composés de l'invention sont utilisés en tant que modulateurs de la gamma-sécrétase. L'invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques comprenant ces composés en tant qu'ingrédient actif ainsi que l'utilisation de ces composés en tant que médicament.
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