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1. WO2013008959 - XENOGRAFT-DERIVED BONE GRAFTING SUBSTITUTE AND METHOD FOR MANUFACTURING SAME

Publication Number WO/2013/008959
Publication Date 17.01.2013
International Application No. PCT/KR2011/005018
International Filing Date 08.07.2011
IPC
A61L 27/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
38Animal cells
A61L 27/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
A61L 27/56 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
56Porous or cellular materials
A61F 2/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
28Bones
A61L 27/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
54Biologically active materials, e.g. therapeutic substances
A61L 27/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof
CPC
A61F 2002/2835
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
28Bones
2835Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
A61L 2300/414
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40characterised by a specific therapeutic activity or mode of action
412Tissue-regenerating or healing or proliferative agents
414Growth factors
A61L 2430/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
02for reconstruction of bones; weight-bearing implants
A61L 2430/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
40Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
A61L 27/3608
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3604characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
3608Bone, e.g. demineralised bone matrix [DBM], bone powder
A61L 27/365
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3641characterised by the site of application in the body
3645Connective tissue
365Bones
Applicants
  • 서울대학교산학협력단 SEOUL NATIONAL UNIVERSITY R and DB FOUNDATION [KR]/[KR] (AllExceptUS)
  • 주식회사 나이벡 NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO, LTD. [KR]/[KR] (AllExceptUS)
  • 정종평 CHUNG, Chong-Pyoung [KR]/[KR] (UsOnly)
  • 박윤정 PARK, Yoon-Jeong [KR]/[KR] (UsOnly)
  • 이주연 LEE, Jue-Yeon [KR]/[KR] (UsOnly)
  • 이상훈 RHEE, Sang Hoon [KR]/[KR] (UsOnly)
Inventors
  • 정종평 CHUNG, Chong-Pyoung
  • 박윤정 PARK, Yoon-Jeong
  • 이주연 LEE, Jue-Yeon
  • 이상훈 RHEE, Sang Hoon
Agents
  • 이처영 LEE, Cheo Young
Priority Data
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) XENOGRAFT-DERIVED BONE GRAFTING SUBSTITUTE AND METHOD FOR MANUFACTURING SAME
(FR) SUBSTITUT DE GREFFON OSSEUX DÉRIVÉ D'UNE XÉNOGREFFE ET SON PROCÉDÉ DE FABRICATION
(KO) 이종골 유래 골이식재 및 그 제조방법
Abstract
(EN)
The present invention relates to a xenograft-derived bone grafting substitute, which has superior biocompatibility, cell adhesion, and osteoconduction, and to a method for producing same. The method for producing the bone grafting substitute according to the present invention enables production of a bone grafting substitute which, compared with existing xenograft-derived bone grafting substitutes, has superior biocompatibility due to a lower protein content and which can fuse well in the tissues of a graft site without an inflammatory reaction, and furthermore, the method can provide improved osteoblast adhesion by treating surfaces of the bone grafting substitute with an acidic amino acid, and can provide improved conduction of newly-generated bone by introducing a bioactive factor.
(FR)
Cette invention concerne un substitut de greffon osseux dérivé d'une xénogreffe, ledit substitut présentant une biocompatibilité supérieure, une adhésion cellulaire plus forte et une meilleure ostéoconduction. L'invention concerne également un procédé de fabrication du substitut de greffon osseux, ledit procédé permettant d'obtenir un substitut de greffon qui, comparé aux autres substituts de greffon osseux dérivés d'une xénogreffe, présente une biocompatibilité supérieure en raison d'un taux inférieur en protéine, et peut fusionner correctement dans les tissus du site de transplantation sans susciter de réaction inflammatoire. Le procédé permet par ailleurs de renforcer l'adhésion des ostéoblastes en traitant les surfaces du substitut du greffon osseux avec un acide aminé acide, et permet également d'améliorer la conduction de l'os néoformé en introduisant un facteur bioactif.
(KO)
본 발명은 이종골을 사용하여 생체적합성, 세포부착능 및 골전도성이 우수한 골이식재 및 그 제조방법에 관한 것이다. 본 발명에 따른 골이식재 제조방법은 기존의 이종골 유래 골이식재에 비해 단백질의 함량이 낮아 생체적합성이 우수하여 이식부위의 조직에서 염증반응 없이 잘 융합될 수 있는 골이식재를 제공할 수 있을 뿐만 아니라, 산성 아미노산으로 표면을 처리함으로써 골세포의 부착능을 증가시킬 수 있고, 생리활성인자를 도입하여 신생골의 전도도 향상시킬 수 있다.
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