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1. WO2013008872 - NOVEL COMPOUND HAVING PARP INHIBITORY ACTIVITY

Publication Number WO/2013/008872
Publication Date 17.01.2013
International Application No. PCT/JP2012/067775
International Filing Date 12.07.2012
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 31/5377 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/551 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 47/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
A61K 9/0095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0087Galenical forms not covered by A61K9/02 - A61K9/7023
0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor; ; Other semi-solid forms, e.g. creams, sticks, gels
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Applicants
  • 参天製薬株式会社 SANTEN PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • 本田 崇宏 HONDA, Takahiro [JP]/[JP] (UsOnly)
  • 榎本 裕志 ENOMOTO, Hiroshi [JP]/[JP] (UsOnly)
  • 川島 健二 KAWASHIMA, Kenji [JP]/[JP] (UsOnly)
  • 高岡 慎治 TAKAOKA, Shinji [JP]/[JP] (UsOnly)
  • 藤岡 恭丘 FUJIOKA, Yasutaka [JP]/[JP] (UsOnly)
  • 松田 学 MATSUDA, Mamoru [JP]/[JP] (UsOnly)
  • 大橋 康司 OHASHI, Koji [JP]/[JP] (UsOnly)
  • 藤田 由紀恵 FUJITA, Yukie [JP]/[JP] (UsOnly)
  • 平井 慎一郎 HIRAI, Shin-ichiro [JP]/[JP] (UsOnly)
  • 倉島 宏明 KURASHIMA, Hiroaki [JP]/[JP] (UsOnly)
Inventors
  • 本田 崇宏 HONDA, Takahiro
  • 榎本 裕志 ENOMOTO, Hiroshi
  • 川島 健二 KAWASHIMA, Kenji
  • 高岡 慎治 TAKAOKA, Shinji
  • 藤岡 恭丘 FUJIOKA, Yasutaka
  • 松田 学 MATSUDA, Mamoru
  • 大橋 康司 OHASHI, Koji
  • 藤田 由紀恵 FUJITA, Yukie
  • 平井 慎一郎 HIRAI, Shin-ichiro
  • 倉島 宏明 KURASHIMA, Hiroaki
Agents
  • 特許業務法人深見特許事務所 Fukami Patent Office, p.c.
Priority Data
2011-15463613.07.2011JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL COMPOUND HAVING PARP INHIBITORY ACTIVITY
(FR) NOUVEAU COMPOSÉ AYANT UNE ACTIVITÉ D'INHIBITION DE PARP
(JA) PARP阻害活性を有する新規化合物
Abstract
(EN)
A compound represented by general formula (1) or a salt thereof. R1 represents a halogen atom or the like; R2 and R3 represent a hydrogen atom or the like; R4 and R5 represent a hydrogen atom or the like or R4 and R5 may form an oxo group; Ra and Rb represent an optionally substituted lower alkyl group or the like or may bond and form a nitrogen-containing heterocycle optionally substituted by one or multiple Rc; Rc represents an optionally substituted aryl group or the like; ring A represents a benzene ring or the like; m represents 0, 1, or 2.
(FR)
L'invention concerne un composé représenté par la formule générale (1) ou un de ses sels. R1 représente un atome d'halogène ou analogue ; R2 et R3 représentent un atome d'hydrogène ou analogue ; R4 et R5 représentent un atome d'hydrogène ou analogue ou R4 et R5 peuvent former un groupe oxo ; Ra et Rb représentent un groupe alkyle inférieur éventuellement substitué ou analogue ou peuvent être reliés et former un hétérocycle contenant de l'azote éventuellement substitué par un ou plusieurs Rc ; Rc représente un groupe aryle éventuellement substitué ou analogue ; le cycle A représente un cycle benzène ou analogue ; m représente 0, 1 ou 2.
(JA)
 下記一般式(1)で表される化合物またはその塩。Rはハロゲン原子などを示し;RおよびRは水素原子などを示し;RおよびRは水素原子などを示すか、または、RとRでオキソ基を形成してもよく;RおよびRは置換基を有してもよい低級アルキル基などを示すか、または、結合して1または複数個のRで置換されてもよい含窒素複素環を形成してもよく;Rは置換基を有してもよいアリール基などを示し;環Aはベンゼン環などを示し;mは0、1または2を示す。 
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