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1. WO2013008093 - TERPENE ANALOGUES AND USES THEREOF FOR TREATING NEUROLOGICAL CONDITIONS

Publication Number WO/2013/008093
Publication Date 17.01.2013
International Application No. PCT/IB2012/001390
International Filing Date 13.07.2012
IPC
C07C 43/176 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
43Ethers; Compounds having groups, groups or groups
02Ethers
03having all ether-oxygen atoms bound to acyclic carbon atoms
14Unsaturated ethers
17containing halogen
174containing six-membered aromatic rings
176having unsaturation outside the aromatic rings
A61K 31/045 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/075 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
A61P 25/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 25/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
C07C 33/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
33Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
28Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
30monocyclic
CPC
A61K 31/045
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
C07C 2601/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
02with a three-membered ring
C07C 33/05
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
33Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
05Alcohols containing rings other than six-membered aromatic rings
C07C 33/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
33Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
38Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
C07C 43/162
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
43Ethers; Compounds having groups, groups or groups
02Ethers
03having all ether-oxygen atoms bound to acyclic carbon atoms
14Unsaturated ethers
162containing rings other than six-membered aromatic rings
Applicants
  • NEUROQUEST INC. [CA]/[CA] (AllExceptUS)
  • MCLELLAN, Alexander [CA]/[CA] (UsOnly)
  • SUN, Shengguo [CA]/[CA] (UsOnly)
  • WEAVER, Donald, F. [CA]/[CA] (UsOnly)
  • REED, Mark, Andrew [CA]/[CA] (UsOnly)
Inventors
  • MCLELLAN, Alexander
  • SUN, Shengguo
  • WEAVER, Donald, F.
  • REED, Mark, Andrew
Common Representative
  • NEUROQUEST INC. [CA]/[CA]
Priority Data
61/507,76414.07.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TERPENE ANALOGUES AND USES THEREOF FOR TREATING NEUROLOGICAL CONDITIONS
(FR) ANALOGUES DU TERPÈNE ET LEURS UTILISATIONS EN VUE DU TRAITEMENT D'AFFECTIONS NEUROLOGIQUES
Abstract
(EN)
The present application provides terpene analogues of Formula 1 and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain specifically.(Formula I) (I) wherein: Y is a C1 to C20 alkylene, C=0, SO, S02, or absent; X is H, OR1, N-(R2)2, a C1to C20 alkyl, or a heterocyclyl (for example, heteroaryl), wherein when Y is absent X is not H; R1 is H, a C1 to C20 alkyl, or a CH2-aryl; R2 is independently H, a C1 to C20 alkyl, aryl, OR1, CN or C(=0)-R3; R3 is a substituted or unsubstituted C1 to C20 alkyl, or a aryl; W is H, C1 to C20 alkyl, or aryl; and Z is C1 to C2o alkylene; or a pharmaceutically acceptable isomer, salt or ester thereof. These terpene analogues are useful in treating pain and can also be used to treat other electrical disorders in the central and peripheral nervous system.
(FR)
La présente demande de brevet concerne des analogues du terpène de formule 1 et des méthodes d'utilisation de ceux-ci à des fins de traitement d'affections neurologiques, telles que la douleur en général et la douleur neuropathique en particulier.(Formule I) (I) dans laquelle Y représente un alkylène en C1 à C20, C=0, SO, S02 ou est absent ; X représente H, OR1, N-(R2)2, un alkyle en C1 à C20 ou un hétérocyclyle (par exemple, un hétéroaryle), sachant que lorsque Y est absent, X ne peut représenter H ; R1 représente H, un alkyle en C1 à C20 ou un CH2-aryle ; R2 représente, indépendamment du reste, H, un aryle, un alkyle en C1 à C20, OR1, CN ou C(=0)-R3 ; R3 représente un alkyle substitué ou non substitué en C1 à C20 ou un aryle ; W représente H, un aryle ou un alkyle en C1 à C20 ; et Z représente un alkylène en C1 à C2o ; ou un ester, un sel ou un isomère pharmaceutiquement acceptable de ceux-ci. Ces analogues du terpène peuvent être utilisés en vue du traitement de la douleur, ainsi que d'autres désordres électriques affectant le système nerveux central et périphérique.
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