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1. WO2013007768 - TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JAK INHIBITORS

Publication Number WO/2013/007768
Publication Date 17.01.2013
International Application No. PCT/EP2012/063632
International Filing Date 12.07.2012
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4375
the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C07D 471/04 (2006.01)
C07D 471/14 (2006.01)
A61K 31/4375 (2006.01)
A61P 35/00 (2006.01)
A61P 37/00 (2006.01)
CPC
C07D 471/04
C07D 471/14
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
  • HURLEY, Christopher [GB/GB]; GB (UsOnly)
  • KULAGOWSKI, Janusz [GB/GB]; GB (UsOnly)
  • ZAK, Mark [CA/US]; US (UsOnly)
Inventors
  • HURLEY, Christopher; GB
  • KULAGOWSKI, Janusz; GB
  • ZAK, Mark; US
Agents
  • SCHIRLIN, Julien; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data
61/507,52813.07.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JAK INHIBITORS
(FR) COMPOSÉS HÉTÉROCYCLIQUES TRICYCLIQUES, COMPOSITIONS ET PROCÉDÉS D'UTILISATION DE CES COMPOSÉS COMME INHIBITEURS DES JAK
Abstract
(EN)
The invention provides novel compounds of formula I having the general formula:(I) wherein Rl s R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
(FR)
L'invention concerne de nouveaux composés de la formule I ayant la formule générale : (I) dans laquelle Rl s R2, R3, X et Y sont tels que décrits dans le descriptif. En conséquence, lesdits composés peuvent être présentés dans des compositions pharmaceutiquement acceptables et utilisés pour le traitement de troubles immunologiques ou hyperprolifératifs.
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